Kinetic Resolution of Racemic Amines to Enantiopure (<i>S</i>)-amines by a Biocatalytic Cascade Employing Amine Dehydrogenase and Alanine Dehydrogenase

Kinetic Resolution of Racemic Amines to Enantiopure (<i>S</i>)-amines by a Biocatalytic Cascade Employing Amine Dehydrogenase and Alanine Dehydrogenase

Amine dehydrogenases (AmDHs) efficiently catalyze the NAD(P)H-dependent asymmetric reductive amination of prochiral carbonyl substrates with high enantioselectivity. AmDH-catalyzed oxidative deamination can also be used for the kinetic resolution of racemic amines to obtain enantiopure amines. In th...

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Bibliographic Details
Main Authors: Mahesh D. Patil, Sanghan Yoon, Hyunwoo Jeon, Taresh P. Khobragade, Sharad Sarak, Amol D. Pagar, Yumi Won, Hyungdon Yun
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Catalysts
Subjects:
amine dehydrogenase
alanine dehydrogenase
chiral amines
kinetic resolution
whole-cell biotransformations
oxidative deamination
Online Access:https://www.mdpi.com/2073-4344/9/7/600

Internet

https://www.mdpi.com/2073-4344/9/7/600

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