Elevated Serum Lysophosphatidylcholine in Patients with Systemic Lupus Erythematosus Impairs Phagocytosis of Necrotic Cells In Vitro

Elevated Serum Lysophosphatidylcholine in Patients with Systemic Lupus Erythematosus Impairs Phagocytosis of Necrotic Cells In Vitro

ObjectivesImpaired clearance of dying and dead cells by professional and amateur phagocytes plays a crucial role in the etiology of systemic lupus erythematosus (SLE). While dying, cells expose and release a plethora of eat-me and find-me signals to ensure their timely removal before entering the da...

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Bibliographic Details
Main Authors: Gerhard E. Grossmayer, Hildegard Keppeler, Sebastian Boeltz, Christina Janko, Jürgen Rech, Martin Herrmann, Kirsten Lauber, Luis E. Muñoz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
rheumatoid arthritis
efferocytosis
lysophosphatidylcholine
phagocytosis
necrotic cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01876/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01876/full

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