Prior Hypoxia Exposure Enhances Murine Microglial Inflammatory Gene Expression in vitro Without Concomitant H3K4me3 Enrichment

Hypoxia (Hx) is a component of multiple disorders, including stroke and sleep-disordered breathing, which often precede or are comorbid with neurodegenerative diseases. However, little is known about how hypoxia affects the ability of microglia, resident CNS macrophages, to respond to subsequent inf...

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Bibliographic Details
Main Authors: Elizabeth A. Kiernan, Andrea C. Ewald, Jonathan N. Ouellette, Tao Wang, Abiye Agbeh, Andrew O. Knutson, Avtar S. Roopra, Jyoti J. Watters
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.535549/full