The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells

The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells

Metabolic reprogramming of tumour cells sustains cancer progression. Similar to other cancer cells, glioblastoma cells exhibit an increased glycolytic flow, which encourages the use of antiglycolytics as an effective complementary therapy. We used the antiglycolytic 3-bromopyruvate (3BP) as a metabo...

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Bibliographic Details
Main Authors: Maya Petricciuolo, Magdalena Davidescu, Katia Fettucciari, Leonardo Gatticchi, Stefano Brancorsini, Rita Roberti, Lanfranco Corazzi, Lara Macchioni
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Heliyon
Subjects:
Glioblastoma cells
3-Bromopyruvate
Mitochondrial ROS
Cytochrome c
Antimycin A
Menadione
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020325846

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http://www.sciencedirect.com/science/article/pii/S2405844020325846

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