Optimal, minimax and admissible two-stage design for phase II oncology clinical trials

Optimal, minimax and admissible two-stage design for phase II oncology clinical trials

Abstract Background The article aims to compare the efficiency of minimax, optimal and admissible criteria in Simon’s and Fleming’s two-stage design. Methods Three parameter settings (p 1-p 0 = 0.25–0.05, 0.30–0.10, 0.50–0.30) are designed to compare the maximum sample size, the critical values and...

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Bibliographic Details
Main Authors: Fei Qin, Jingwei Wu, Feng Chen, Yongyue Wei, Yang Zhao, Zhiwei Jiang, Jianling Bai, Hao Yu
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Medical Research Methodology
Subjects:
Optimal design
Minimax design
Admissible design
Online Access:http://link.springer.com/article/10.1186/s12874-020-01017-8

Internet

http://link.springer.com/article/10.1186/s12874-020-01017-8

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