Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Summary: Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of tran...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-04-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221112471830425X |
id |
doaj-f473a4993a0c4b9696aa018ccddbb472 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hua-Sheng Chiu Sonal Somvanshi Ektaben Patel Ting-Wen Chen Vivek P. Singh Barry Zorman Sagar L. Patil Yinghong Pan Sujash S. Chatterjee Anil K. Sood Preethi H. Gunaratne Pavel Sumazin Samantha J. Caesar-Johnson John A. Demchok Ina Felau Melpomeni Kasapi Martin L. Ferguson Carolyn M. Hutter Heidi J. Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C. Zenklusen Jiashan (Julia) Zhang Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Juok Cho Timothy DeFreitas Scott Frazer Nils Gehlenborg Gad Getz David I. Heiman Jaegil Kim Michael S. Lawrence Pei Lin Sam Meier Michael S. Noble Gordon Saksena Doug Voet Hailei Zhang Brady Bernard Nyasha Chambwe Varsha Dhankani Theo Knijnenburg Roger Kramer Kalle Leinonen Yuexin Liu Michael Miller Sheila Reynolds Ilya Shmulevich Vesteinn Thorsson Wei Zhang Rehan Akbani Bradley M. Broom Apurva M. Hegde Zhenlin Ju Rupa S. Kanchi Anil Korkut Jun Li Han Liang Shiyun Ling Wenbin Liu Yiling Lu Gordon B. Mills Kwok-Shing Ng Arvind Rao Michael Ryan Jing Wang John N. Weinstein Jiexin Zhang Adam Abeshouse Joshua Armenia Debyani Chakravarty Walid K. Chatila Ino de Bruijn Jianjiong Gao Benjamin E. Gross Zachary J. Heins Ritika Kundra Konnor La Marc Ladanyi Augustin Luna Moriah G. Nissan Angelica Ochoa Sarah M. Phillips Ed Reznik Francisco Sanchez-Vega Chris Sander Nikolaus Schultz Robert Sheridan S. Onur Sumer Yichao Sun Barry S. Taylor Jioajiao Wang Hongxin Zhang Pavana Anur Myron Peto Paul Spellman Christopher Benz Joshua M. Stuart Christopher K. Wong Christina Yau D. Neil Hayes Joel S. Parker Matthew D. Wilkerson Adrian Ally Miruna Balasundaram Reanne Bowlby Denise Brooks Rebecca Carlsen Eric Chuah Noreen Dhalla Robert Holt Steven J.M. Jones Katayoon Kasaian Darlene Lee Yussanne Ma Marco A. Marra Michael Mayo Richard A. Moore Andrew J. Mungall Karen Mungall A. Gordon Robertson Sara Sadeghi Jacqueline E. Schein Payal Sipahimalani Angela Tam Nina Thiessen Kane Tse Tina Wong Ashton C. Berger Rameen Beroukhim Andrew D. Cherniack Carrie Cibulskis Stacey B. Gabriel Galen F. Gao Gavin Ha Matthew Meyerson Steven E. Schumacher Juliann Shih Melanie H. Kucherlapati Raju S. Kucherlapati Stephen Baylin Leslie Cope Ludmila Danilova Moiz S. Bootwalla Phillip H. Lai Dennis T. Maglinte David J. Van Den Berg Daniel J. Weisenberger J. Todd Auman Saianand Balu Tom Bodenheimer Cheng Fan Katherine A. Hoadley Alan P. Hoyle Stuart R. Jefferys Corbin D. Jones Shaowu Meng Piotr A. Mieczkowski Lisle E. Mose Amy H. Perou Charles M. Perou Jeffrey Roach Yan Shi Janae V. Simons Tara Skelly Matthew G. Soloway Donghui Tan Umadevi Veluvolu Huihui Fan Toshinori Hinoue Peter W. Laird Hui Shen Wanding Zhou Michelle Bellair Kyle Chang Kyle Covington Chad J. Creighton Huyen Dinh HarshaVardhan Doddapaneni Lawrence A. Donehower Jennifer Drummond Richard A. Gibbs Robert Glenn Walker Hale Yi Han Jianhong Hu Viktoriya Korchina Sandra Lee Lora Lewis Wei Li Xiuping Liu Margaret Morgan Donna Morton Donna Muzny Jireh Santibanez Margi Sheth Eve Shinbrot Linghua Wang Min Wang David A. Wheeler Liu Xi Fengmei Zhao Julian Hess Elizabeth L. Appelbaum Matthew Bailey Matthew G. Cordes Li Ding Catrina C. Fronick Lucinda A. Fulton Robert S. Fulton Cyriac Kandoth Elaine R. Mardis Michael D. McLellan Christopher A. Miller Heather K. Schmidt Richard K. Wilson Daniel Crain Erin Curley Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Candace Shelton Troy Shelton Mark Sherman Eric Thompson Peggy Yena Jay Bowen Julie M. Gastier-Foster Mark Gerken Kristen M. Leraas Tara M. Lichtenberg Nilsa C. Ramirez Lisa Wise Erik Zmuda Niall Corcoran Tony Costello Christopher Hovens Andre L. Carvalho Ana C. de Carvalho José H. Fregnani Adhemar Longatto-Filho Rui M. Reis Cristovam Scapulatempo-Neto Henrique C.S. Silveira Daniel O. Vidal Andrew Burnette Jennifer Eschbacher Beth Hermes Ardene Noss Rosy Singh Matthew L. Anderson Patricia D. Castro Michael Ittmann David Huntsman Bernard Kohl Xuan Le Richard Thorp Chris Andry Elizabeth R. Duffy Vladimir Lyadov Oxana Paklina Galiya Setdikova Alexey Shabunin Mikhail Tavobilov Christopher McPherson Ronald Warnick Ross Berkowitz Daniel Cramer Colleen Feltmate Neil Horowitz Adam Kibel Michael Muto Chandrajit P. Raut Andrei Malykh Jill S. Barnholtz-Sloan Wendi Barrett Karen Devine Jordonna Fulop Quinn T. Ostrom Kristen Shimmel Yingli Wolinsky Andrew E. Sloan Agostino De Rose Felice Giuliante Marc Goodman Beth Y. Karlan Curt H. Hagedorn John Eckman Jodi Harr Jerome Myers Kelinda Tucker Leigh Anne Zach Brenda Deyarmin Hai Hu Leonid Kvecher Caroline Larson Richard J. Mural Stella Somiari Ales Vicha Tomas Zelinka Joseph Bennett Mary Iacocca Brenda Rabeno Patricia Swanson Mathieu Latour Louis Lacombe Bernard Têtu Alain Bergeron Mary McGraw Susan M. Staugaitis John Chabot Hanina Hibshoosh Antonia Sepulveda Tao Su Timothy Wang Olga Potapova Olga Voronina Laurence Desjardins Odette Mariani Sergio Roman-Roman Xavier Sastre Marc-Henri Stern Feixiong Cheng Sabina Signoretti Andrew Berchuck Darell Bigner Eric Lipp Jeffrey Marks Shannon McCall Roger McLendon Angeles Secord Alexis Sharp Madhusmita Behera Daniel J. Brat Amy Chen Keith Delman Seth Force Fadlo Khuri Kelly Magliocca Shishir Maithel Jeffrey J. Olson Taofeek Owonikoko Alan Pickens Suresh Ramalingam Dong M. Shin Gabriel Sica Erwin G. Van Meir Hongzheng Zhang Wil Eijckenboom Ad Gillis Esther Korpershoek Leendert Looijenga Wolter Oosterhuis Hans Stoop Kim E. van Kessel Ellen C. Zwarthoff Chiara Calatozzolo Lucia Cuppini Stefania Cuzzubbo Francesco DiMeco Gaetano Finocchiaro Luca Mattei Alessandro Perin Bianca Pollo Chu Chen John Houck Pawadee Lohavanichbutr Arndt Hartmann Christine Stoehr Robert Stoehr Helge Taubert Sven Wach Bernd Wullich Witold Kycler Dawid Murawa Maciej Wiznerowicz Ki Chung W. Jeffrey Edenfield Julie Martin Eric Baudin Glenn Bubley Raphael Bueno Assunta De Rienzo William G. Richards Steven Kalkanis Tom Mikkelsen Houtan Noushmehr Lisa Scarpace Nicolas Girard Marta Aymerich Elias Campo Eva Giné Armando López Guillermo Nguyen Van Bang Phan Thi Hanh Bui Duc Phu Yufang Tang Howard Colman Kimberley Evason Peter R. Dottino John A. Martignetti Hani Gabra Hartmut Juhl Teniola Akeredolu Serghei Stepa Dave Hoon Keunsoo Ahn Koo Jeong Kang Felix Beuschlein Anne Breggia Michael Birrer Debra Bell Mitesh Borad Alan H. Bryce Erik Castle Vishal Chandan John Cheville John A. Copland Michael Farnell Thomas Flotte Nasra Giama Thai Ho Michael Kendrick Jean-Pierre Kocher Karla Kopp Catherine Moser David Nagorney Daniel O’Brien Brian Patrick O’Neill Tushar Patel Gloria Petersen Florencia Que Michael Rivera Lewis Roberts Robert Smallridge Thomas Smyrk Melissa Stanton R. Houston Thompson Michael Torbenson Ju Dong Yang Lizhi Zhang Fadi Brimo Jaffer A. Ajani Ana Maria Angulo Gonzalez Carmen Behrens Jolanta Bondaruk Russell Broaddus Bogdan Czerniak Bita Esmaeli Junya Fujimoto Jeffrey Gershenwald Charles Guo Alexander J. Lazar Christopher Logothetis Funda Meric-Bernstam Cesar Moran Lois Ramondetta David Rice Anil Sood Pheroze Tamboli Timothy Thompson Patricia Troncoso Anne Tsao Ignacio Wistuba Candace Carter Lauren Haydu Peter Hersey Valerie Jakrot Hojabr Kakavand Richard Kefford Kenneth Lee Georgina Long Graham Mann Michael Quinn Robyn Saw Richard Scolyer Kerwin Shannon Andrew Spillane Jonathan Stretch Maria Synott John Thompson James Wilmott Hikmat Al-Ahmadie Timothy A. Chan Ronald Ghossein Anuradha Gopalan Douglas A. Levine Victor Reuter Samuel Singer Bhuvanesh Singh Nguyen Viet Tien Thomas Broudy Cyrus Mirsaidi Praveen Nair Paul Drwiega Judy Miller Jennifer Smith Howard Zaren Joong-Won Park Nguyen Phi Hung Electron Kebebew W. Marston Linehan Adam R. Metwalli Karel Pacak Peter A. Pinto Mark Schiffman Laura S. Schmidt Cathy D. Vocke Nicolas Wentzensen Robert Worrell Hannah Yang Marc Moncrieff Chandra Goparaju Jonathan Melamed Harvey Pass Natalia Botnariuc Irina Caraman Mircea Cernat Inga Chemencedji Adrian Clipca Serghei Doruc Ghenadie Gorincioi Sergiu Mura Maria Pirtac Irina Stancul Diana Tcaciuc Monique Albert Iakovina Alexopoulou Angel Arnaout John Bartlett Jay Engel Sebastien Gilbert Jeremy Parfitt Harman Sekhon George Thomas Doris M. Rassl Robert C. Rintoul Carlo Bifulco Raina Tamakawa Walter Urba Nicholas Hayward Henri Timmers Anna Antenucci Francesco Facciolo Gianluca Grazi Mirella Marino Roberta Merola Ronald de Krijger Anne-Paule Gimenez-Roqueplo Alain Piché Simone Chevalier Ginette McKercher Kivanc Birsoy Gene Barnett Cathy Brewer Carol Farver Theresa Naska Nathan A. Pennell Daniel Raymond Cathy Schilero Kathy Smolenski Felicia Williams Carl Morrison Jeffrey A. Borgia Michael J. Liptay Mark Pool Christopher W. Seder Kerstin Junker Larsson Omberg Mikhail Dinkin George Manikhas Domenico Alvaro Maria Consiglia Bragazzi Vincenzo Cardinale Guido Carpino Eugenio Gaudio David Chesla Sandra Cottingham Michael Dubina Fedor Moiseenko Renumathy Dhanasekaran Karl-Friedrich Becker Klaus-Peter Janssen Julia Slotta-Huspenina Mohamed H. Abdel-Rahman Dina Aziz Sue Bell Colleen M. Cebulla Amy Davis Rebecca Duell J. Bradley Elder Joe Hilty Bahavna Kumar James Lang Norman L. Lehman Randy Mandt Phuong Nguyen Robert Pilarski Karan Rai Lynn Schoenfield Kelly Senecal Paul Wakely Paul Hansen Ronald Lechan James Powers Arthur Tischler William E. Grizzle Katherine C. Sexton Alison Kastl Joel Henderson Sima Porten Jens Waldmann Martin Fassnacht Sylvia L. Asa Dirk Schadendorf Marta Couce Markus Graefen Hartwig Huland Guido Sauter Thorsten Schlomm Ronald Simon Pierre Tennstedt Oluwole Olabode Mark Nelson Oliver Bathe Peter R. Carroll June M. Chan Philip Disaia Pat Glenn Robin K. Kelley Charles N. Landen Joanna Phillips Michael Prados Jeffry Simko Karen Smith-McCune Scott VandenBerg Kevin Roggin Ashley Fehrenbach Ady Kendler Suzanne Sifri Ruth Steele Antonio Jimeno Francis Carey Ian Forgie Massimo Mannelli Michael Carney Brenda Hernandez Benito Campos Christel Herold-Mende Christin Jungk Andreas Unterberg Andreas von Deimling Aaron Bossler Joseph Galbraith Laura Jacobus Michael Knudson Tina Knutson Deqin Ma Mohammed Milhem Rita Sigmund Andrew K. Godwin Rashna Madan Howard G. Rosenthal Clement Adebamowo Sally N. Adebamowo Alex Boussioutas David Beer Thomas Giordano Anne-Marie Mes-Masson Fred Saad Therese Bocklage Lisa Landrum Robert Mannel Kathleen Moore Katherine Moxley Russel Postier Joan Walker Rosemary Zuna Michael Feldman Federico Valdivieso Rajiv Dhir James Luketich Edna M. Mora Pinero Mario Quintero-Aguilo Carlos Gilberto Carlotti, Jr. Jose Sebastião Dos Santos Rafael Kemp Ajith Sankarankuty Daniela Tirapelli James Catto Kathy Agnew Elizabeth Swisher Jenette Creaney Bruce Robinson Carl Simon Shelley Eryn M. Godwin Sara Kendall Cassaundra Shipman Carol Bradford Thomas Carey Andrea Haddad Jeffey Moyer Lisa Peterson Mark Prince Laura Rozek Gregory Wolf Rayleen Bowman Kwun M. Fong Ian Yang Robert Korst W. Kimryn Rathmell J. Leigh Fantacone-Campbell Jeffrey A. Hooke Albert J. Kovatich Craig D. Shriver John DiPersio Bettina Drake Ramaswamy Govindan Sharon Heath Timothy Ley Brian Van Tine Peter Westervelt Mark A. Rubin Jung Il Lee Natália D. Aredes Armaz Mariamidze |
spellingShingle |
Hua-Sheng Chiu Sonal Somvanshi Ektaben Patel Ting-Wen Chen Vivek P. Singh Barry Zorman Sagar L. Patil Yinghong Pan Sujash S. Chatterjee Anil K. Sood Preethi H. Gunaratne Pavel Sumazin Samantha J. Caesar-Johnson John A. Demchok Ina Felau Melpomeni Kasapi Martin L. Ferguson Carolyn M. Hutter Heidi J. Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C. Zenklusen Jiashan (Julia) Zhang Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Juok Cho Timothy DeFreitas Scott Frazer Nils Gehlenborg Gad Getz David I. Heiman Jaegil Kim Michael S. Lawrence Pei Lin Sam Meier Michael S. Noble Gordon Saksena Doug Voet Hailei Zhang Brady Bernard Nyasha Chambwe Varsha Dhankani Theo Knijnenburg Roger Kramer Kalle Leinonen Yuexin Liu Michael Miller Sheila Reynolds Ilya Shmulevich Vesteinn Thorsson Wei Zhang Rehan Akbani Bradley M. Broom Apurva M. Hegde Zhenlin Ju Rupa S. Kanchi Anil Korkut Jun Li Han Liang Shiyun Ling Wenbin Liu Yiling Lu Gordon B. Mills Kwok-Shing Ng Arvind Rao Michael Ryan Jing Wang John N. Weinstein Jiexin Zhang Adam Abeshouse Joshua Armenia Debyani Chakravarty Walid K. Chatila Ino de Bruijn Jianjiong Gao Benjamin E. Gross Zachary J. Heins Ritika Kundra Konnor La Marc Ladanyi Augustin Luna Moriah G. Nissan Angelica Ochoa Sarah M. Phillips Ed Reznik Francisco Sanchez-Vega Chris Sander Nikolaus Schultz Robert Sheridan S. Onur Sumer Yichao Sun Barry S. Taylor Jioajiao Wang Hongxin Zhang Pavana Anur Myron Peto Paul Spellman Christopher Benz Joshua M. Stuart Christopher K. Wong Christina Yau D. Neil Hayes Joel S. Parker Matthew D. Wilkerson Adrian Ally Miruna Balasundaram Reanne Bowlby Denise Brooks Rebecca Carlsen Eric Chuah Noreen Dhalla Robert Holt Steven J.M. Jones Katayoon Kasaian Darlene Lee Yussanne Ma Marco A. Marra Michael Mayo Richard A. Moore Andrew J. Mungall Karen Mungall A. Gordon Robertson Sara Sadeghi Jacqueline E. Schein Payal Sipahimalani Angela Tam Nina Thiessen Kane Tse Tina Wong Ashton C. Berger Rameen Beroukhim Andrew D. Cherniack Carrie Cibulskis Stacey B. Gabriel Galen F. Gao Gavin Ha Matthew Meyerson Steven E. Schumacher Juliann Shih Melanie H. Kucherlapati Raju S. Kucherlapati Stephen Baylin Leslie Cope Ludmila Danilova Moiz S. Bootwalla Phillip H. Lai Dennis T. Maglinte David J. Van Den Berg Daniel J. Weisenberger J. Todd Auman Saianand Balu Tom Bodenheimer Cheng Fan Katherine A. Hoadley Alan P. Hoyle Stuart R. Jefferys Corbin D. Jones Shaowu Meng Piotr A. Mieczkowski Lisle E. Mose Amy H. Perou Charles M. Perou Jeffrey Roach Yan Shi Janae V. Simons Tara Skelly Matthew G. Soloway Donghui Tan Umadevi Veluvolu Huihui Fan Toshinori Hinoue Peter W. Laird Hui Shen Wanding Zhou Michelle Bellair Kyle Chang Kyle Covington Chad J. Creighton Huyen Dinh HarshaVardhan Doddapaneni Lawrence A. Donehower Jennifer Drummond Richard A. Gibbs Robert Glenn Walker Hale Yi Han Jianhong Hu Viktoriya Korchina Sandra Lee Lora Lewis Wei Li Xiuping Liu Margaret Morgan Donna Morton Donna Muzny Jireh Santibanez Margi Sheth Eve Shinbrot Linghua Wang Min Wang David A. Wheeler Liu Xi Fengmei Zhao Julian Hess Elizabeth L. Appelbaum Matthew Bailey Matthew G. Cordes Li Ding Catrina C. Fronick Lucinda A. Fulton Robert S. Fulton Cyriac Kandoth Elaine R. Mardis Michael D. McLellan Christopher A. Miller Heather K. Schmidt Richard K. Wilson Daniel Crain Erin Curley Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Candace Shelton Troy Shelton Mark Sherman Eric Thompson Peggy Yena Jay Bowen Julie M. Gastier-Foster Mark Gerken Kristen M. Leraas Tara M. Lichtenberg Nilsa C. Ramirez Lisa Wise Erik Zmuda Niall Corcoran Tony Costello Christopher Hovens Andre L. Carvalho Ana C. de Carvalho José H. Fregnani Adhemar Longatto-Filho Rui M. Reis Cristovam Scapulatempo-Neto Henrique C.S. Silveira Daniel O. Vidal Andrew Burnette Jennifer Eschbacher Beth Hermes Ardene Noss Rosy Singh Matthew L. Anderson Patricia D. Castro Michael Ittmann David Huntsman Bernard Kohl Xuan Le Richard Thorp Chris Andry Elizabeth R. Duffy Vladimir Lyadov Oxana Paklina Galiya Setdikova Alexey Shabunin Mikhail Tavobilov Christopher McPherson Ronald Warnick Ross Berkowitz Daniel Cramer Colleen Feltmate Neil Horowitz Adam Kibel Michael Muto Chandrajit P. Raut Andrei Malykh Jill S. Barnholtz-Sloan Wendi Barrett Karen Devine Jordonna Fulop Quinn T. Ostrom Kristen Shimmel Yingli Wolinsky Andrew E. Sloan Agostino De Rose Felice Giuliante Marc Goodman Beth Y. Karlan Curt H. Hagedorn John Eckman Jodi Harr Jerome Myers Kelinda Tucker Leigh Anne Zach Brenda Deyarmin Hai Hu Leonid Kvecher Caroline Larson Richard J. Mural Stella Somiari Ales Vicha Tomas Zelinka Joseph Bennett Mary Iacocca Brenda Rabeno Patricia Swanson Mathieu Latour Louis Lacombe Bernard Têtu Alain Bergeron Mary McGraw Susan M. Staugaitis John Chabot Hanina Hibshoosh Antonia Sepulveda Tao Su Timothy Wang Olga Potapova Olga Voronina Laurence Desjardins Odette Mariani Sergio Roman-Roman Xavier Sastre Marc-Henri Stern Feixiong Cheng Sabina Signoretti Andrew Berchuck Darell Bigner Eric Lipp Jeffrey Marks Shannon McCall Roger McLendon Angeles Secord Alexis Sharp Madhusmita Behera Daniel J. Brat Amy Chen Keith Delman Seth Force Fadlo Khuri Kelly Magliocca Shishir Maithel Jeffrey J. Olson Taofeek Owonikoko Alan Pickens Suresh Ramalingam Dong M. Shin Gabriel Sica Erwin G. Van Meir Hongzheng Zhang Wil Eijckenboom Ad Gillis Esther Korpershoek Leendert Looijenga Wolter Oosterhuis Hans Stoop Kim E. van Kessel Ellen C. Zwarthoff Chiara Calatozzolo Lucia Cuppini Stefania Cuzzubbo Francesco DiMeco Gaetano Finocchiaro Luca Mattei Alessandro Perin Bianca Pollo Chu Chen John Houck Pawadee Lohavanichbutr Arndt Hartmann Christine Stoehr Robert Stoehr Helge Taubert Sven Wach Bernd Wullich Witold Kycler Dawid Murawa Maciej Wiznerowicz Ki Chung W. Jeffrey Edenfield Julie Martin Eric Baudin Glenn Bubley Raphael Bueno Assunta De Rienzo William G. Richards Steven Kalkanis Tom Mikkelsen Houtan Noushmehr Lisa Scarpace Nicolas Girard Marta Aymerich Elias Campo Eva Giné Armando López Guillermo Nguyen Van Bang Phan Thi Hanh Bui Duc Phu Yufang Tang Howard Colman Kimberley Evason Peter R. Dottino John A. Martignetti Hani Gabra Hartmut Juhl Teniola Akeredolu Serghei Stepa Dave Hoon Keunsoo Ahn Koo Jeong Kang Felix Beuschlein Anne Breggia Michael Birrer Debra Bell Mitesh Borad Alan H. Bryce Erik Castle Vishal Chandan John Cheville John A. Copland Michael Farnell Thomas Flotte Nasra Giama Thai Ho Michael Kendrick Jean-Pierre Kocher Karla Kopp Catherine Moser David Nagorney Daniel O’Brien Brian Patrick O’Neill Tushar Patel Gloria Petersen Florencia Que Michael Rivera Lewis Roberts Robert Smallridge Thomas Smyrk Melissa Stanton R. Houston Thompson Michael Torbenson Ju Dong Yang Lizhi Zhang Fadi Brimo Jaffer A. Ajani Ana Maria Angulo Gonzalez Carmen Behrens Jolanta Bondaruk Russell Broaddus Bogdan Czerniak Bita Esmaeli Junya Fujimoto Jeffrey Gershenwald Charles Guo Alexander J. Lazar Christopher Logothetis Funda Meric-Bernstam Cesar Moran Lois Ramondetta David Rice Anil Sood Pheroze Tamboli Timothy Thompson Patricia Troncoso Anne Tsao Ignacio Wistuba Candace Carter Lauren Haydu Peter Hersey Valerie Jakrot Hojabr Kakavand Richard Kefford Kenneth Lee Georgina Long Graham Mann Michael Quinn Robyn Saw Richard Scolyer Kerwin Shannon Andrew Spillane Jonathan Stretch Maria Synott John Thompson James Wilmott Hikmat Al-Ahmadie Timothy A. Chan Ronald Ghossein Anuradha Gopalan Douglas A. Levine Victor Reuter Samuel Singer Bhuvanesh Singh Nguyen Viet Tien Thomas Broudy Cyrus Mirsaidi Praveen Nair Paul Drwiega Judy Miller Jennifer Smith Howard Zaren Joong-Won Park Nguyen Phi Hung Electron Kebebew W. Marston Linehan Adam R. Metwalli Karel Pacak Peter A. Pinto Mark Schiffman Laura S. Schmidt Cathy D. Vocke Nicolas Wentzensen Robert Worrell Hannah Yang Marc Moncrieff Chandra Goparaju Jonathan Melamed Harvey Pass Natalia Botnariuc Irina Caraman Mircea Cernat Inga Chemencedji Adrian Clipca Serghei Doruc Ghenadie Gorincioi Sergiu Mura Maria Pirtac Irina Stancul Diana Tcaciuc Monique Albert Iakovina Alexopoulou Angel Arnaout John Bartlett Jay Engel Sebastien Gilbert Jeremy Parfitt Harman Sekhon George Thomas Doris M. Rassl Robert C. Rintoul Carlo Bifulco Raina Tamakawa Walter Urba Nicholas Hayward Henri Timmers Anna Antenucci Francesco Facciolo Gianluca Grazi Mirella Marino Roberta Merola Ronald de Krijger Anne-Paule Gimenez-Roqueplo Alain Piché Simone Chevalier Ginette McKercher Kivanc Birsoy Gene Barnett Cathy Brewer Carol Farver Theresa Naska Nathan A. Pennell Daniel Raymond Cathy Schilero Kathy Smolenski Felicia Williams Carl Morrison Jeffrey A. Borgia Michael J. Liptay Mark Pool Christopher W. Seder Kerstin Junker Larsson Omberg Mikhail Dinkin George Manikhas Domenico Alvaro Maria Consiglia Bragazzi Vincenzo Cardinale Guido Carpino Eugenio Gaudio David Chesla Sandra Cottingham Michael Dubina Fedor Moiseenko Renumathy Dhanasekaran Karl-Friedrich Becker Klaus-Peter Janssen Julia Slotta-Huspenina Mohamed H. Abdel-Rahman Dina Aziz Sue Bell Colleen M. Cebulla Amy Davis Rebecca Duell J. Bradley Elder Joe Hilty Bahavna Kumar James Lang Norman L. Lehman Randy Mandt Phuong Nguyen Robert Pilarski Karan Rai Lynn Schoenfield Kelly Senecal Paul Wakely Paul Hansen Ronald Lechan James Powers Arthur Tischler William E. Grizzle Katherine C. Sexton Alison Kastl Joel Henderson Sima Porten Jens Waldmann Martin Fassnacht Sylvia L. Asa Dirk Schadendorf Marta Couce Markus Graefen Hartwig Huland Guido Sauter Thorsten Schlomm Ronald Simon Pierre Tennstedt Oluwole Olabode Mark Nelson Oliver Bathe Peter R. Carroll June M. Chan Philip Disaia Pat Glenn Robin K. Kelley Charles N. Landen Joanna Phillips Michael Prados Jeffry Simko Karen Smith-McCune Scott VandenBerg Kevin Roggin Ashley Fehrenbach Ady Kendler Suzanne Sifri Ruth Steele Antonio Jimeno Francis Carey Ian Forgie Massimo Mannelli Michael Carney Brenda Hernandez Benito Campos Christel Herold-Mende Christin Jungk Andreas Unterberg Andreas von Deimling Aaron Bossler Joseph Galbraith Laura Jacobus Michael Knudson Tina Knutson Deqin Ma Mohammed Milhem Rita Sigmund Andrew K. Godwin Rashna Madan Howard G. Rosenthal Clement Adebamowo Sally N. Adebamowo Alex Boussioutas David Beer Thomas Giordano Anne-Marie Mes-Masson Fred Saad Therese Bocklage Lisa Landrum Robert Mannel Kathleen Moore Katherine Moxley Russel Postier Joan Walker Rosemary Zuna Michael Feldman Federico Valdivieso Rajiv Dhir James Luketich Edna M. Mora Pinero Mario Quintero-Aguilo Carlos Gilberto Carlotti, Jr. Jose Sebastião Dos Santos Rafael Kemp Ajith Sankarankuty Daniela Tirapelli James Catto Kathy Agnew Elizabeth Swisher Jenette Creaney Bruce Robinson Carl Simon Shelley Eryn M. Godwin Sara Kendall Cassaundra Shipman Carol Bradford Thomas Carey Andrea Haddad Jeffey Moyer Lisa Peterson Mark Prince Laura Rozek Gregory Wolf Rayleen Bowman Kwun M. Fong Ian Yang Robert Korst W. Kimryn Rathmell J. Leigh Fantacone-Campbell Jeffrey A. Hooke Albert J. Kovatich Craig D. Shriver John DiPersio Bettina Drake Ramaswamy Govindan Sharon Heath Timothy Ley Brian Van Tine Peter Westervelt Mark A. Rubin Jung Il Lee Natália D. Aredes Armaz Mariamidze Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context Cell Reports |
author_facet |
Hua-Sheng Chiu Sonal Somvanshi Ektaben Patel Ting-Wen Chen Vivek P. Singh Barry Zorman Sagar L. Patil Yinghong Pan Sujash S. Chatterjee Anil K. Sood Preethi H. Gunaratne Pavel Sumazin Samantha J. Caesar-Johnson John A. Demchok Ina Felau Melpomeni Kasapi Martin L. Ferguson Carolyn M. Hutter Heidi J. Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C. Zenklusen Jiashan (Julia) Zhang Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Juok Cho Timothy DeFreitas Scott Frazer Nils Gehlenborg Gad Getz David I. Heiman Jaegil Kim Michael S. Lawrence Pei Lin Sam Meier Michael S. Noble Gordon Saksena Doug Voet Hailei Zhang Brady Bernard Nyasha Chambwe Varsha Dhankani Theo Knijnenburg Roger Kramer Kalle Leinonen Yuexin Liu Michael Miller Sheila Reynolds Ilya Shmulevich Vesteinn Thorsson Wei Zhang Rehan Akbani Bradley M. Broom Apurva M. Hegde Zhenlin Ju Rupa S. Kanchi Anil Korkut Jun Li Han Liang Shiyun Ling Wenbin Liu Yiling Lu Gordon B. Mills Kwok-Shing Ng Arvind Rao Michael Ryan Jing Wang John N. Weinstein Jiexin Zhang Adam Abeshouse Joshua Armenia Debyani Chakravarty Walid K. Chatila Ino de Bruijn Jianjiong Gao Benjamin E. Gross Zachary J. Heins Ritika Kundra Konnor La Marc Ladanyi Augustin Luna Moriah G. Nissan Angelica Ochoa Sarah M. Phillips Ed Reznik Francisco Sanchez-Vega Chris Sander Nikolaus Schultz Robert Sheridan S. Onur Sumer Yichao Sun Barry S. Taylor Jioajiao Wang Hongxin Zhang Pavana Anur Myron Peto Paul Spellman Christopher Benz Joshua M. Stuart Christopher K. Wong Christina Yau D. Neil Hayes Joel S. Parker Matthew D. Wilkerson Adrian Ally Miruna Balasundaram Reanne Bowlby Denise Brooks Rebecca Carlsen Eric Chuah Noreen Dhalla Robert Holt Steven J.M. Jones Katayoon Kasaian Darlene Lee Yussanne Ma Marco A. Marra Michael Mayo Richard A. Moore Andrew J. Mungall Karen Mungall A. Gordon Robertson Sara Sadeghi Jacqueline E. Schein Payal Sipahimalani Angela Tam Nina Thiessen Kane Tse Tina Wong Ashton C. Berger Rameen Beroukhim Andrew D. Cherniack Carrie Cibulskis Stacey B. Gabriel Galen F. Gao Gavin Ha Matthew Meyerson Steven E. Schumacher Juliann Shih Melanie H. Kucherlapati Raju S. Kucherlapati Stephen Baylin Leslie Cope Ludmila Danilova Moiz S. Bootwalla Phillip H. Lai Dennis T. Maglinte David J. Van Den Berg Daniel J. Weisenberger J. Todd Auman Saianand Balu Tom Bodenheimer Cheng Fan Katherine A. Hoadley Alan P. Hoyle Stuart R. Jefferys Corbin D. Jones Shaowu Meng Piotr A. Mieczkowski Lisle E. Mose Amy H. Perou Charles M. Perou Jeffrey Roach Yan Shi Janae V. Simons Tara Skelly Matthew G. Soloway Donghui Tan Umadevi Veluvolu Huihui Fan Toshinori Hinoue Peter W. Laird Hui Shen Wanding Zhou Michelle Bellair Kyle Chang Kyle Covington Chad J. Creighton Huyen Dinh HarshaVardhan Doddapaneni Lawrence A. Donehower Jennifer Drummond Richard A. Gibbs Robert Glenn Walker Hale Yi Han Jianhong Hu Viktoriya Korchina Sandra Lee Lora Lewis Wei Li Xiuping Liu Margaret Morgan Donna Morton Donna Muzny Jireh Santibanez Margi Sheth Eve Shinbrot Linghua Wang Min Wang David A. Wheeler Liu Xi Fengmei Zhao Julian Hess Elizabeth L. Appelbaum Matthew Bailey Matthew G. Cordes Li Ding Catrina C. Fronick Lucinda A. Fulton Robert S. Fulton Cyriac Kandoth Elaine R. Mardis Michael D. McLellan Christopher A. Miller Heather K. Schmidt Richard K. Wilson Daniel Crain Erin Curley Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Candace Shelton Troy Shelton Mark Sherman Eric Thompson Peggy Yena Jay Bowen Julie M. Gastier-Foster Mark Gerken Kristen M. Leraas Tara M. Lichtenberg Nilsa C. Ramirez Lisa Wise Erik Zmuda Niall Corcoran Tony Costello Christopher Hovens Andre L. Carvalho Ana C. de Carvalho José H. Fregnani Adhemar Longatto-Filho Rui M. Reis Cristovam Scapulatempo-Neto Henrique C.S. Silveira Daniel O. Vidal Andrew Burnette Jennifer Eschbacher Beth Hermes Ardene Noss Rosy Singh Matthew L. Anderson Patricia D. Castro Michael Ittmann David Huntsman Bernard Kohl Xuan Le Richard Thorp Chris Andry Elizabeth R. Duffy Vladimir Lyadov Oxana Paklina Galiya Setdikova Alexey Shabunin Mikhail Tavobilov Christopher McPherson Ronald Warnick Ross Berkowitz Daniel Cramer Colleen Feltmate Neil Horowitz Adam Kibel Michael Muto Chandrajit P. Raut Andrei Malykh Jill S. Barnholtz-Sloan Wendi Barrett Karen Devine Jordonna Fulop Quinn T. Ostrom Kristen Shimmel Yingli Wolinsky Andrew E. Sloan Agostino De Rose Felice Giuliante Marc Goodman Beth Y. Karlan Curt H. Hagedorn John Eckman Jodi Harr Jerome Myers Kelinda Tucker Leigh Anne Zach Brenda Deyarmin Hai Hu Leonid Kvecher Caroline Larson Richard J. Mural Stella Somiari Ales Vicha Tomas Zelinka Joseph Bennett Mary Iacocca Brenda Rabeno Patricia Swanson Mathieu Latour Louis Lacombe Bernard Têtu Alain Bergeron Mary McGraw Susan M. Staugaitis John Chabot Hanina Hibshoosh Antonia Sepulveda Tao Su Timothy Wang Olga Potapova Olga Voronina Laurence Desjardins Odette Mariani Sergio Roman-Roman Xavier Sastre Marc-Henri Stern Feixiong Cheng Sabina Signoretti Andrew Berchuck Darell Bigner Eric Lipp Jeffrey Marks Shannon McCall Roger McLendon Angeles Secord Alexis Sharp Madhusmita Behera Daniel J. Brat Amy Chen Keith Delman Seth Force Fadlo Khuri Kelly Magliocca Shishir Maithel Jeffrey J. Olson Taofeek Owonikoko Alan Pickens Suresh Ramalingam Dong M. Shin Gabriel Sica Erwin G. Van Meir Hongzheng Zhang Wil Eijckenboom Ad Gillis Esther Korpershoek Leendert Looijenga Wolter Oosterhuis Hans Stoop Kim E. van Kessel Ellen C. Zwarthoff Chiara Calatozzolo Lucia Cuppini Stefania Cuzzubbo Francesco DiMeco Gaetano Finocchiaro Luca Mattei Alessandro Perin Bianca Pollo Chu Chen John Houck Pawadee Lohavanichbutr Arndt Hartmann Christine Stoehr Robert Stoehr Helge Taubert Sven Wach Bernd Wullich Witold Kycler Dawid Murawa Maciej Wiznerowicz Ki Chung W. Jeffrey Edenfield Julie Martin Eric Baudin Glenn Bubley Raphael Bueno Assunta De Rienzo William G. Richards Steven Kalkanis Tom Mikkelsen Houtan Noushmehr Lisa Scarpace Nicolas Girard Marta Aymerich Elias Campo Eva Giné Armando López Guillermo Nguyen Van Bang Phan Thi Hanh Bui Duc Phu Yufang Tang Howard Colman Kimberley Evason Peter R. Dottino John A. Martignetti Hani Gabra Hartmut Juhl Teniola Akeredolu Serghei Stepa Dave Hoon Keunsoo Ahn Koo Jeong Kang Felix Beuschlein Anne Breggia Michael Birrer Debra Bell Mitesh Borad Alan H. Bryce Erik Castle Vishal Chandan John Cheville John A. Copland Michael Farnell Thomas Flotte Nasra Giama Thai Ho Michael Kendrick Jean-Pierre Kocher Karla Kopp Catherine Moser David Nagorney Daniel O’Brien Brian Patrick O’Neill Tushar Patel Gloria Petersen Florencia Que Michael Rivera Lewis Roberts Robert Smallridge Thomas Smyrk Melissa Stanton R. Houston Thompson Michael Torbenson Ju Dong Yang Lizhi Zhang Fadi Brimo Jaffer A. Ajani Ana Maria Angulo Gonzalez Carmen Behrens Jolanta Bondaruk Russell Broaddus Bogdan Czerniak Bita Esmaeli Junya Fujimoto Jeffrey Gershenwald Charles Guo Alexander J. Lazar Christopher Logothetis Funda Meric-Bernstam Cesar Moran Lois Ramondetta David Rice Anil Sood Pheroze Tamboli Timothy Thompson Patricia Troncoso Anne Tsao Ignacio Wistuba Candace Carter Lauren Haydu Peter Hersey Valerie Jakrot Hojabr Kakavand Richard Kefford Kenneth Lee Georgina Long Graham Mann Michael Quinn Robyn Saw Richard Scolyer Kerwin Shannon Andrew Spillane Jonathan Stretch Maria Synott John Thompson James Wilmott Hikmat Al-Ahmadie Timothy A. Chan Ronald Ghossein Anuradha Gopalan Douglas A. Levine Victor Reuter Samuel Singer Bhuvanesh Singh Nguyen Viet Tien Thomas Broudy Cyrus Mirsaidi Praveen Nair Paul Drwiega Judy Miller Jennifer Smith Howard Zaren Joong-Won Park Nguyen Phi Hung Electron Kebebew W. Marston Linehan Adam R. Metwalli Karel Pacak Peter A. Pinto Mark Schiffman Laura S. Schmidt Cathy D. Vocke Nicolas Wentzensen Robert Worrell Hannah Yang Marc Moncrieff Chandra Goparaju Jonathan Melamed Harvey Pass Natalia Botnariuc Irina Caraman Mircea Cernat Inga Chemencedji Adrian Clipca Serghei Doruc Ghenadie Gorincioi Sergiu Mura Maria Pirtac Irina Stancul Diana Tcaciuc Monique Albert Iakovina Alexopoulou Angel Arnaout John Bartlett Jay Engel Sebastien Gilbert Jeremy Parfitt Harman Sekhon George Thomas Doris M. Rassl Robert C. Rintoul Carlo Bifulco Raina Tamakawa Walter Urba Nicholas Hayward Henri Timmers Anna Antenucci Francesco Facciolo Gianluca Grazi Mirella Marino Roberta Merola Ronald de Krijger Anne-Paule Gimenez-Roqueplo Alain Piché Simone Chevalier Ginette McKercher Kivanc Birsoy Gene Barnett Cathy Brewer Carol Farver Theresa Naska Nathan A. Pennell Daniel Raymond Cathy Schilero Kathy Smolenski Felicia Williams Carl Morrison Jeffrey A. Borgia Michael J. Liptay Mark Pool Christopher W. Seder Kerstin Junker Larsson Omberg Mikhail Dinkin George Manikhas Domenico Alvaro Maria Consiglia Bragazzi Vincenzo Cardinale Guido Carpino Eugenio Gaudio David Chesla Sandra Cottingham Michael Dubina Fedor Moiseenko Renumathy Dhanasekaran Karl-Friedrich Becker Klaus-Peter Janssen Julia Slotta-Huspenina Mohamed H. Abdel-Rahman Dina Aziz Sue Bell Colleen M. Cebulla Amy Davis Rebecca Duell J. Bradley Elder Joe Hilty Bahavna Kumar James Lang Norman L. Lehman Randy Mandt Phuong Nguyen Robert Pilarski Karan Rai Lynn Schoenfield Kelly Senecal Paul Wakely Paul Hansen Ronald Lechan James Powers Arthur Tischler William E. Grizzle Katherine C. Sexton Alison Kastl Joel Henderson Sima Porten Jens Waldmann Martin Fassnacht Sylvia L. Asa Dirk Schadendorf Marta Couce Markus Graefen Hartwig Huland Guido Sauter Thorsten Schlomm Ronald Simon Pierre Tennstedt Oluwole Olabode Mark Nelson Oliver Bathe Peter R. Carroll June M. Chan Philip Disaia Pat Glenn Robin K. Kelley Charles N. Landen Joanna Phillips Michael Prados Jeffry Simko Karen Smith-McCune Scott VandenBerg Kevin Roggin Ashley Fehrenbach Ady Kendler Suzanne Sifri Ruth Steele Antonio Jimeno Francis Carey Ian Forgie Massimo Mannelli Michael Carney Brenda Hernandez Benito Campos Christel Herold-Mende Christin Jungk Andreas Unterberg Andreas von Deimling Aaron Bossler Joseph Galbraith Laura Jacobus Michael Knudson Tina Knutson Deqin Ma Mohammed Milhem Rita Sigmund Andrew K. Godwin Rashna Madan Howard G. Rosenthal Clement Adebamowo Sally N. Adebamowo Alex Boussioutas David Beer Thomas Giordano Anne-Marie Mes-Masson Fred Saad Therese Bocklage Lisa Landrum Robert Mannel Kathleen Moore Katherine Moxley Russel Postier Joan Walker Rosemary Zuna Michael Feldman Federico Valdivieso Rajiv Dhir James Luketich Edna M. Mora Pinero Mario Quintero-Aguilo Carlos Gilberto Carlotti, Jr. Jose Sebastião Dos Santos Rafael Kemp Ajith Sankarankuty Daniela Tirapelli James Catto Kathy Agnew Elizabeth Swisher Jenette Creaney Bruce Robinson Carl Simon Shelley Eryn M. Godwin Sara Kendall Cassaundra Shipman Carol Bradford Thomas Carey Andrea Haddad Jeffey Moyer Lisa Peterson Mark Prince Laura Rozek Gregory Wolf Rayleen Bowman Kwun M. Fong Ian Yang Robert Korst W. Kimryn Rathmell J. Leigh Fantacone-Campbell Jeffrey A. Hooke Albert J. Kovatich Craig D. Shriver John DiPersio Bettina Drake Ramaswamy Govindan Sharon Heath Timothy Ley Brian Van Tine Peter Westervelt Mark A. Rubin Jung Il Lee Natália D. Aredes Armaz Mariamidze |
author_sort |
Hua-Sheng Chiu |
title |
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context |
title_short |
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context |
title_full |
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context |
title_fullStr |
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context |
title_full_unstemmed |
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context |
title_sort |
pan-cancer analysis of lncrna regulation supports their targeting of cancer genes in each tumor context |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2018-04-01 |
description |
Summary: Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs) whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts. To demonstrate proof of concept, we showed that perturbations targeting OIP5-AS1 (an inferred tumor suppressor) and TUG1 and WT1-AS (inferred onco-lncRNAs) dysregulated cancer genes and altered proliferation of breast and gynecologic cancer cells. Our analysis indicates that, although most lncRNAs are dysregulated in a tumor-specific manner, some, including OIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergistically dysregulate cancer pathways in multiple tumor contexts. : Chiu et al. present a pan-cancer analysis of lncRNA regulatory interactions. They suggest that the dysregulation of hundreds of lncRNAs target and alter the expression of cancer genes and pathways in each tumor context. This implies that hundreds of lncRNAs can alter tumor phenotypes in each tumor context. Keywords: lncRNA, regulation, modulation, cancer gene, pan-cancer, noncoding RNA, microRNA, RNA-binding proteins, interactome |
url |
http://www.sciencedirect.com/science/article/pii/S221112471830425X |
work_keys_str_mv |
AT huashengchiu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sonalsomvanshi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ektabenpatel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tingwenchen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT vivekpsingh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT barryzorman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sagarlpatil pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yinghongpan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sujashschatterjee pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT anilksood pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT preethihgunaratne pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT pavelsumazin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT samanthajcaesarjohnson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnademchok pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT inafelau pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT melpomenikasapi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT martinlferguson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carolynmhutter pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT heidijsofia pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT roytarnuzzer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT zhiningwang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT limingyang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeanczenklusen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jiashanjuliazhang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sudhachudamani pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jialiu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT laxmilolla pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rashinaresh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT toddpihl pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT qiangsun pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yunhuwan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yewu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT juokcho pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT timothydefreitas pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT scottfrazer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nilsgehlenborg pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gadgetz pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidiheiman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jaegilkim pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelslawrence pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peilin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sammeier pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelsnoble pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gordonsaksena pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dougvoet pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT haileizhang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bradybernard pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nyashachambwe pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT varshadhankani pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT theoknijnenburg pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rogerkramer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kalleleinonen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yuexinliu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelmiller pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sheilareynolds pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ilyashmulevich pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT vesteinnthorsson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT weizhang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rehanakbani pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bradleymbroom pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT apurvamhegde pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT zhenlinju pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rupaskanchi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT anilkorkut pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT junli pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hanliang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT shiyunling pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wenbinliu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yilinglu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gordonbmills pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kwokshingng pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT arvindrao pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelryan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jingwang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnnweinstein pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jiexinzhang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adamabeshouse pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joshuaarmenia pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT debyanichakravarty pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT walidkchatila pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT inodebruijn pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jianjionggao pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT benjaminegross pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT zacharyjheins pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ritikakundra pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT konnorla pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marcladanyi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT augustinluna pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT moriahgnissan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT angelicaochoa pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sarahmphillips pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT edreznik pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT franciscosanchezvega pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chrissander pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nikolausschultz pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertsheridan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sonursumer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yichaosun pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT barrystaylor pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jioajiaowang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hongxinzhang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT pavanaanur pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT myronpeto pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT paulspellman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christopherbenz pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joshuamstuart pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christopherkwong pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christinayau pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dneilhayes pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joelsparker pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT matthewdwilkerson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adrianally pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mirunabalasundaram pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT reannebowlby pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT denisebrooks pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rebeccacarlsen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ericchuah pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT noreendhalla pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertholt pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT stevenjmjones pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT katayoonkasaian pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT darlenelee pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yussannema pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marcoamarra pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelmayo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT richardamoore pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrewjmungall pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT karenmungall pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT agordonrobertson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sarasadeghi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jacquelineeschein pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT payalsipahimalani pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT angelatam pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ninathiessen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kanetse pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tinawong pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ashtoncberger pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rameenberoukhim pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrewdcherniack pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carriecibulskis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT staceybgabriel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT galenfgao pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gavinha pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT matthewmeyerson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT steveneschumacher pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT juliannshih pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT melaniehkucherlapati pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rajuskucherlapati pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT stephenbaylin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lesliecope pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ludmiladanilova pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT moizsbootwalla pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT philliphlai pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dennistmaglinte pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidjvandenberg pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danieljweisenberger pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jtoddauman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT saianandbalu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tombodenheimer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chengfan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT katherineahoadley pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alanphoyle pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT stuartrjefferys pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT corbindjones pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT shaowumeng pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT piotramieczkowski pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lisleemose pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT amyhperou pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT charlesmperou pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffreyroach pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yanshi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT janaevsimons pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT taraskelly pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT matthewgsoloway pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT donghuitan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT umadeviveluvolu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT huihuifan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT toshinorihinoue pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peterwlaird pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT huishen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wandingzhou pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michellebellair pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kylechang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kylecovington pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chadjcreighton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT huyendinh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT harshavardhandoddapaneni pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lawrenceadonehower pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jenniferdrummond pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT richardagibbs pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertglenn pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT walkerhale pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yihan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jianhonghu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT viktoriyakorchina pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sandralee pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT loralewis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT weili pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT xiupingliu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT margaretmorgan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT donnamorton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT donnamuzny pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jirehsantibanez pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT margisheth pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT eveshinbrot pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT linghuawang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT minwang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidawheeler pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT liuxi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT fengmeizhao pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT julianhess pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT elizabethlappelbaum pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT matthewbailey pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT matthewgcordes pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT liding pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT catrinacfronick pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lucindaafulton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertsfulton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cyriackandoth pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT elainermardis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaeldmclellan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christopheramiller pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT heatherkschmidt pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT richardkwilson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danielcrain pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT erincurley pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johannagardner pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kevinlau pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidmallery pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT scottmorris pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT josephpaulauskis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertpenny pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT candaceshelton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT troyshelton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marksherman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ericthompson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peggyyena pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jaybowen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT juliemgastierfoster pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT markgerken pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kristenmleraas pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT taramlichtenberg pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nilsacramirez pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lisawise pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT erikzmuda pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT niallcorcoran pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tonycostello pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christopherhovens pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrelcarvalho pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT anacdecarvalho pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT josehfregnani pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adhemarlongattofilho pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ruimreis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cristovamscapulatemponeto pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT henriquecssilveira pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danielovidal pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrewburnette pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jennifereschbacher pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bethhermes pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ardenenoss pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rosysingh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT matthewlanderson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT patriciadcastro pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelittmann pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidhuntsman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bernardkohl pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT xuanle pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT richardthorp pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chrisandry pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT elizabethrduffy pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT vladimirlyadov pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT oxanapaklina pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT galiyasetdikova pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alexeyshabunin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mikhailtavobilov pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christophermcpherson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ronaldwarnick pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rossberkowitz pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danielcramer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT colleenfeltmate pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT neilhorowitz pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adamkibel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelmuto pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chandrajitpraut pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andreimalykh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jillsbarnholtzsloan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wendibarrett pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT karendevine pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jordonnafulop pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT quinntostrom pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kristenshimmel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yingliwolinsky pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrewesloan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT agostinoderose pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT felicegiuliante pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marcgoodman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bethykarlan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT curthhagedorn pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johneckman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jodiharr pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeromemyers pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kelindatucker pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT leighannezach pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT brendadeyarmin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT haihu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT leonidkvecher pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carolinelarson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT richardjmural pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT stellasomiari pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alesvicha pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tomaszelinka pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT josephbennett pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT maryiacocca pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT brendarabeno pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT patriciaswanson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mathieulatour pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT louislacombe pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bernardtetu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alainbergeron pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marymcgraw pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT susanmstaugaitis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnchabot pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT haninahibshoosh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT antoniasepulveda pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT taosu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT timothywang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT olgapotapova pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT olgavoronina pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT laurencedesjardins pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT odettemariani pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sergioromanroman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT xaviersastre pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marchenristern pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT feixiongcheng pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sabinasignoretti pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrewberchuck pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT darellbigner pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ericlipp pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffreymarks pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT shannonmccall pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rogermclendon pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT angelessecord pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alexissharp pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT madhusmitabehera pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danieljbrat pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT amychen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT keithdelman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sethforce pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT fadlokhuri pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kellymagliocca pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT shishirmaithel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffreyjolson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT taofeekowonikoko pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alanpickens pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sureshramalingam pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dongmshin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gabrielsica pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT erwingvanmeir pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hongzhengzhang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wileijckenboom pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adgillis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT estherkorpershoek pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT leendertlooijenga pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wolteroosterhuis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hansstoop pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kimevankessel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ellenczwarthoff pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chiaracalatozzolo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT luciacuppini pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT stefaniacuzzubbo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT francescodimeco pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gaetanofinocchiaro pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lucamattei pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alessandroperin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT biancapollo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chuchen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnhouck pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT pawadeelohavanichbutr pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT arndthartmann pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christinestoehr pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertstoehr pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT helgetaubert pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT svenwach pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT berndwullich pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT witoldkycler pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dawidmurawa pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT maciejwiznerowicz pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kichung pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wjeffreyedenfield pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT juliemartin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ericbaudin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT glennbubley pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT raphaelbueno pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT assuntaderienzo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT williamgrichards pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT stevenkalkanis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tommikkelsen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT houtannoushmehr pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lisascarpace pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nicolasgirard pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT martaaymerich pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT eliascampo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT evagine pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT armandolopezguillermo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nguyenvanbang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT phanthihanh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT buiducphu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT yufangtang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT howardcolman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kimberleyevason pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peterrdottino pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnamartignetti pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hanigabra pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hartmutjuhl pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT teniolaakeredolu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sergheistepa pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davehoon pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT keunsooahn pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT koojeongkang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT felixbeuschlein pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT annebreggia pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelbirrer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT debrabell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT miteshborad pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alanhbryce pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT erikcastle pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT vishalchandan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johncheville pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnacopland pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelfarnell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT thomasflotte pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nasragiama pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT thaiho pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelkendrick pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeanpierrekocher pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT karlakopp pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT catherinemoser pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidnagorney pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danielobrien pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT brianpatrickoneill pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tusharpatel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gloriapetersen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT florenciaque pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelrivera pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lewisroberts pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertsmallridge pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT thomassmyrk pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT melissastanton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rhoustonthompson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaeltorbenson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT judongyang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lizhizhang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT fadibrimo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jafferaajani pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT anamariaangulogonzalez pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carmenbehrens pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jolantabondaruk pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT russellbroaddus pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bogdanczerniak pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bitaesmaeli pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT junyafujimoto pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffreygershenwald pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT charlesguo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alexanderjlazar pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christopherlogothetis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT fundamericbernstam pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cesarmoran pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT loisramondetta pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidrice pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT anilsood pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT pherozetamboli pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT timothythompson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT patriciatroncoso pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT annetsao pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ignaciowistuba pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT candacecarter pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT laurenhaydu pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peterhersey pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT valeriejakrot pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hojabrkakavand pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT richardkefford pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kennethlee pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT georginalong pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT grahammann pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelquinn pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robynsaw pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT richardscolyer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kerwinshannon pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrewspillane pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jonathanstretch pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mariasynott pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnthompson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jameswilmott pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hikmatalahmadie pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT timothyachan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ronaldghossein pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT anuradhagopalan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT douglasalevine pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT victorreuter pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT samuelsinger pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bhuvaneshsingh pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nguyenviettien pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT thomasbroudy pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cyrusmirsaidi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT praveennair pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT pauldrwiega pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT judymiller pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jennifersmith pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT howardzaren pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joongwonpark pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nguyenphihung pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT electronkebebew pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wmarstonlinehan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adamrmetwalli pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT karelpacak pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peterapinto pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT markschiffman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT laurasschmidt pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cathydvocke pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nicolaswentzensen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertworrell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hannahyang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marcmoncrieff pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT chandragoparaju pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jonathanmelamed pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT harveypass pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nataliabotnariuc pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT irinacaraman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mirceacernat pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ingachemencedji pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adrianclipca pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sergheidoruc pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ghenadiegorincioi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sergiumura pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mariapirtac pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT irinastancul pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dianatcaciuc pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT moniquealbert pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT iakovinaalexopoulou pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT angelarnaout pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johnbartlett pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jayengel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sebastiengilbert pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeremyparfitt pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT harmansekhon pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT georgethomas pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dorismrassl pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertcrintoul pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carlobifulco pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rainatamakawa pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT walterurba pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nicholashayward pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT henritimmers pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT annaantenucci pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT francescofacciolo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gianlucagrazi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mirellamarino pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertamerola pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ronalddekrijger pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT annepaulegimenezroqueplo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alainpiche pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT simonechevalier pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ginettemckercher pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kivancbirsoy pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT genebarnett pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cathybrewer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carolfarver pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT theresanaska pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nathanapennell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danielraymond pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cathyschilero pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kathysmolenski pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT feliciawilliams pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carlmorrison pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffreyaborgia pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaeljliptay pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT markpool pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christopherwseder pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kerstinjunker pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT larssonomberg pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mikhaildinkin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT georgemanikhas pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT domenicoalvaro pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mariaconsigliabragazzi pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT vincenzocardinale pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT guidocarpino pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT eugeniogaudio pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidchesla pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sandracottingham pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaeldubina pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT fedormoiseenko pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT renumathydhanasekaran pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT karlfriedrichbecker pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT klauspeterjanssen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT juliaslottahuspenina pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mohamedhabdelrahman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dinaaziz pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT suebell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT colleenmcebulla pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT amydavis pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rebeccaduell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jbradleyelder pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joehilty pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bahavnakumar pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jameslang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT normanllehman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT randymandt pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT phuongnguyen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertpilarski pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT karanrai pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lynnschoenfield pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kellysenecal pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT paulwakely pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT paulhansen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ronaldlechan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jamespowers pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT arthurtischler pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT williamegrizzle pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT katherinecsexton pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alisonkastl pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joelhenderson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT simaporten pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jenswaldmann pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT martinfassnacht pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sylvialasa pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT dirkschadendorf pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT martacouce pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT markusgraefen pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT hartwighuland pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT guidosauter pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT thorstenschlomm pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ronaldsimon pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT pierretennstedt pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT oluwoleolabode pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marknelson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT oliverbathe pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peterrcarroll pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT junemchan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT philipdisaia pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT patglenn pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robinkkelley pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT charlesnlanden pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joannaphillips pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelprados pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffrysimko pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT karensmithmccune pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT scottvandenberg pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kevinroggin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ashleyfehrenbach pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT adykendler pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT suzannesifri pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ruthsteele pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT antoniojimeno pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT franciscarey pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ianforgie pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT massimomannelli pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelcarney pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT brendahernandez pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT benitocampos pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christelheroldmende pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT christinjungk pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andreasunterberg pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andreasvondeimling pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT aaronbossler pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT josephgalbraith pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT laurajacobus pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelknudson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT tinaknutson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT deqinma pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT mohammedmilhem pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ritasigmund pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andrewkgodwin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rashnamadan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT howardgrosenthal pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT clementadebamowo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sallynadebamowo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT alexboussioutas pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT davidbeer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT thomasgiordano pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT annemariemesmasson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT fredsaad pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT theresebocklage pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lisalandrum pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertmannel pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kathleenmoore pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT katherinemoxley pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT russelpostier pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT joanwalker pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rosemaryzuna pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT michaelfeldman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT federicovaldivieso pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rajivdhir pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jamesluketich pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ednammorapinero pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT marioquinteroaguilo pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carlosgilbertocarlottijr pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT josesebastiaodossantos pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rafaelkemp pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ajithsankarankuty pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT danielatirapelli pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jamescatto pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kathyagnew pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT elizabethswisher pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jenettecreaney pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT brucerobinson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carlsimonshelley pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT erynmgodwin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sarakendall pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT cassaundrashipman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT carolbradford pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT thomascarey pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT andreahaddad pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffeymoyer pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT lisapeterson pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT markprince pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT laurarozek pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT gregorywolf pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT rayleenbowman pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT kwunmfong pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ianyang pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT robertkorst pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT wkimrynrathmell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jleighfantaconecampbell pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jeffreyahooke pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT albertjkovatich pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT craigdshriver pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT johndipersio pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT bettinadrake pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT ramaswamygovindan pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT sharonheath pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT timothyley pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT brianvantine pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT peterwestervelt pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT markarubin pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT jungillee pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT nataliadaredes pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext AT armazmariamidze pancanceranalysisoflncrnaregulationsupportstheirtargetingofcancergenesineachtumorcontext |
_version_ |
1725179937392951296 |
spelling |
doaj-f473a4993a0c4b9696aa018ccddbb4722020-11-25T01:09:08ZengElsevierCell Reports2211-12472018-04-01231297312.e12Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor ContextHua-Sheng Chiu0Sonal Somvanshi1Ektaben Patel2Ting-Wen Chen3Vivek P. Singh4Barry Zorman5Sagar L. Patil6Yinghong Pan7Sujash S. Chatterjee8Anil K. Sood9Preethi H. Gunaratne10Pavel Sumazin11Samantha J. Caesar-JohnsonJohn A. DemchokIna FelauMelpomeni KasapiMartin L. FergusonCarolyn M. HutterHeidi J. SofiaRoy TarnuzzerZhining WangLiming YangJean C. ZenklusenJiashan (Julia) ZhangSudha ChudamaniJia LiuLaxmi LollaRashi NareshTodd PihlQiang SunYunhu WanYe WuJuok ChoTimothy DeFreitasScott FrazerNils GehlenborgGad GetzDavid I. HeimanJaegil KimMichael S. LawrencePei LinSam MeierMichael S. NobleGordon SaksenaDoug VoetHailei ZhangBrady BernardNyasha ChambweVarsha DhankaniTheo KnijnenburgRoger KramerKalle LeinonenYuexin LiuMichael MillerSheila ReynoldsIlya ShmulevichVesteinn ThorssonWei ZhangRehan AkbaniBradley M. BroomApurva M. HegdeZhenlin JuRupa S. KanchiAnil KorkutJun LiHan LiangShiyun LingWenbin LiuYiling LuGordon B. MillsKwok-Shing NgArvind RaoMichael RyanJing WangJohn N. WeinsteinJiexin ZhangAdam AbeshouseJoshua ArmeniaDebyani ChakravartyWalid K. ChatilaIno de BruijnJianjiong GaoBenjamin E. GrossZachary J. HeinsRitika KundraKonnor LaMarc LadanyiAugustin LunaMoriah G. NissanAngelica OchoaSarah M. PhillipsEd ReznikFrancisco Sanchez-VegaChris SanderNikolaus SchultzRobert SheridanS. Onur SumerYichao SunBarry S. TaylorJioajiao WangHongxin ZhangPavana AnurMyron PetoPaul SpellmanChristopher BenzJoshua M. StuartChristopher K. WongChristina YauD. Neil HayesJoel S. ParkerMatthew D. WilkersonAdrian AllyMiruna BalasundaramReanne BowlbyDenise BrooksRebecca CarlsenEric ChuahNoreen DhallaRobert HoltSteven J.M. JonesKatayoon KasaianDarlene LeeYussanne MaMarco A. MarraMichael MayoRichard A. MooreAndrew J. MungallKaren MungallA. Gordon RobertsonSara SadeghiJacqueline E. ScheinPayal SipahimalaniAngela TamNina ThiessenKane TseTina WongAshton C. BergerRameen BeroukhimAndrew D. CherniackCarrie CibulskisStacey B. GabrielGalen F. GaoGavin HaMatthew MeyersonSteven E. SchumacherJuliann ShihMelanie H. KucherlapatiRaju S. KucherlapatiStephen BaylinLeslie CopeLudmila DanilovaMoiz S. BootwallaPhillip H. LaiDennis T. MaglinteDavid J. Van Den BergDaniel J. WeisenbergerJ. Todd AumanSaianand BaluTom BodenheimerCheng FanKatherine A. HoadleyAlan P. HoyleStuart R. JefferysCorbin D. JonesShaowu MengPiotr A. MieczkowskiLisle E. MoseAmy H. PerouCharles M. PerouJeffrey RoachYan ShiJanae V. SimonsTara SkellyMatthew G. SolowayDonghui TanUmadevi VeluvoluHuihui FanToshinori HinouePeter W. LairdHui ShenWanding ZhouMichelle BellairKyle ChangKyle CovingtonChad J. CreightonHuyen DinhHarshaVardhan DoddapaneniLawrence A. DonehowerJennifer DrummondRichard A. GibbsRobert GlennWalker HaleYi HanJianhong HuViktoriya KorchinaSandra LeeLora LewisWei LiXiuping LiuMargaret MorganDonna MortonDonna MuznyJireh SantibanezMargi ShethEve ShinbrotLinghua WangMin WangDavid A. WheelerLiu XiFengmei ZhaoJulian HessElizabeth L. AppelbaumMatthew BaileyMatthew G. CordesLi DingCatrina C. FronickLucinda A. FultonRobert S. FultonCyriac KandothElaine R. MardisMichael D. McLellanChristopher A. MillerHeather K. SchmidtRichard K. WilsonDaniel CrainErin CurleyJohanna GardnerKevin LauDavid MalleryScott MorrisJoseph PaulauskisRobert PennyCandace SheltonTroy SheltonMark ShermanEric ThompsonPeggy YenaJay BowenJulie M. Gastier-FosterMark GerkenKristen M. LeraasTara M. LichtenbergNilsa C. RamirezLisa WiseErik ZmudaNiall CorcoranTony CostelloChristopher HovensAndre L. CarvalhoAna C. de CarvalhoJosé H. FregnaniAdhemar Longatto-FilhoRui M. ReisCristovam Scapulatempo-NetoHenrique C.S. SilveiraDaniel O. VidalAndrew BurnetteJennifer EschbacherBeth HermesArdene NossRosy SinghMatthew L. AndersonPatricia D. CastroMichael IttmannDavid HuntsmanBernard KohlXuan LeRichard ThorpChris AndryElizabeth R. DuffyVladimir LyadovOxana PaklinaGaliya SetdikovaAlexey ShabuninMikhail TavobilovChristopher McPhersonRonald WarnickRoss BerkowitzDaniel CramerColleen FeltmateNeil HorowitzAdam KibelMichael MutoChandrajit P. RautAndrei MalykhJill S. Barnholtz-SloanWendi BarrettKaren DevineJordonna FulopQuinn T. OstromKristen ShimmelYingli WolinskyAndrew E. SloanAgostino De RoseFelice GiulianteMarc GoodmanBeth Y. KarlanCurt H. HagedornJohn EckmanJodi HarrJerome MyersKelinda TuckerLeigh Anne ZachBrenda DeyarminHai HuLeonid KvecherCaroline LarsonRichard J. MuralStella SomiariAles VichaTomas ZelinkaJoseph BennettMary IacoccaBrenda RabenoPatricia SwansonMathieu LatourLouis LacombeBernard TêtuAlain BergeronMary McGrawSusan M. StaugaitisJohn ChabotHanina HibshooshAntonia SepulvedaTao SuTimothy WangOlga PotapovaOlga VoroninaLaurence DesjardinsOdette MarianiSergio Roman-RomanXavier SastreMarc-Henri SternFeixiong ChengSabina SignorettiAndrew BerchuckDarell BignerEric LippJeffrey MarksShannon McCallRoger McLendonAngeles SecordAlexis SharpMadhusmita BeheraDaniel J. BratAmy ChenKeith DelmanSeth ForceFadlo KhuriKelly MaglioccaShishir MaithelJeffrey J. OlsonTaofeek OwonikokoAlan PickensSuresh RamalingamDong M. ShinGabriel SicaErwin G. Van MeirHongzheng ZhangWil EijckenboomAd GillisEsther KorpershoekLeendert LooijengaWolter OosterhuisHans StoopKim E. van KesselEllen C. ZwarthoffChiara CalatozzoloLucia CuppiniStefania CuzzubboFrancesco DiMecoGaetano FinocchiaroLuca MatteiAlessandro PerinBianca PolloChu ChenJohn HouckPawadee LohavanichbutrArndt HartmannChristine StoehrRobert StoehrHelge TaubertSven WachBernd WullichWitold KyclerDawid MurawaMaciej WiznerowiczKi ChungW. Jeffrey EdenfieldJulie MartinEric BaudinGlenn BubleyRaphael BuenoAssunta De RienzoWilliam G. RichardsSteven KalkanisTom MikkelsenHoutan NoushmehrLisa ScarpaceNicolas GirardMarta AymerichElias CampoEva GinéArmando López GuillermoNguyen Van BangPhan Thi HanhBui Duc PhuYufang TangHoward ColmanKimberley EvasonPeter R. DottinoJohn A. MartignettiHani GabraHartmut JuhlTeniola AkeredoluSerghei StepaDave HoonKeunsoo AhnKoo Jeong KangFelix BeuschleinAnne BreggiaMichael BirrerDebra BellMitesh BoradAlan H. BryceErik CastleVishal ChandanJohn ChevilleJohn A. CoplandMichael FarnellThomas FlotteNasra GiamaThai HoMichael KendrickJean-Pierre KocherKarla KoppCatherine MoserDavid NagorneyDaniel O’BrienBrian Patrick O’NeillTushar PatelGloria PetersenFlorencia QueMichael RiveraLewis RobertsRobert SmallridgeThomas SmyrkMelissa StantonR. Houston ThompsonMichael TorbensonJu Dong YangLizhi ZhangFadi BrimoJaffer A. AjaniAna Maria Angulo GonzalezCarmen BehrensJolanta BondarukRussell BroaddusBogdan CzerniakBita EsmaeliJunya FujimotoJeffrey GershenwaldCharles GuoAlexander J. LazarChristopher LogothetisFunda Meric-BernstamCesar MoranLois RamondettaDavid RiceAnil SoodPheroze TamboliTimothy ThompsonPatricia TroncosoAnne TsaoIgnacio WistubaCandace CarterLauren HayduPeter HerseyValerie JakrotHojabr KakavandRichard KeffordKenneth LeeGeorgina LongGraham MannMichael QuinnRobyn SawRichard ScolyerKerwin ShannonAndrew SpillaneJonathan StretchMaria SynottJohn ThompsonJames WilmottHikmat Al-AhmadieTimothy A. ChanRonald GhosseinAnuradha GopalanDouglas A. LevineVictor ReuterSamuel SingerBhuvanesh SinghNguyen Viet TienThomas BroudyCyrus MirsaidiPraveen NairPaul DrwiegaJudy MillerJennifer SmithHoward ZarenJoong-Won ParkNguyen Phi HungElectron KebebewW. Marston LinehanAdam R. MetwalliKarel PacakPeter A. PintoMark SchiffmanLaura S. SchmidtCathy D. VockeNicolas WentzensenRobert WorrellHannah YangMarc MoncrieffChandra GoparajuJonathan MelamedHarvey PassNatalia BotnariucIrina CaramanMircea CernatInga ChemencedjiAdrian ClipcaSerghei DorucGhenadie GorincioiSergiu MuraMaria PirtacIrina StanculDiana TcaciucMonique AlbertIakovina AlexopoulouAngel ArnaoutJohn BartlettJay EngelSebastien GilbertJeremy ParfittHarman SekhonGeorge ThomasDoris M. RasslRobert C. RintoulCarlo BifulcoRaina TamakawaWalter UrbaNicholas HaywardHenri TimmersAnna AntenucciFrancesco FaccioloGianluca GraziMirella MarinoRoberta MerolaRonald de KrijgerAnne-Paule Gimenez-RoqueploAlain PichéSimone ChevalierGinette McKercherKivanc BirsoyGene BarnettCathy BrewerCarol FarverTheresa NaskaNathan A. PennellDaniel RaymondCathy SchileroKathy SmolenskiFelicia WilliamsCarl MorrisonJeffrey A. BorgiaMichael J. LiptayMark PoolChristopher W. SederKerstin JunkerLarsson OmbergMikhail DinkinGeorge ManikhasDomenico AlvaroMaria Consiglia BragazziVincenzo CardinaleGuido CarpinoEugenio GaudioDavid CheslaSandra CottinghamMichael DubinaFedor MoiseenkoRenumathy DhanasekaranKarl-Friedrich BeckerKlaus-Peter JanssenJulia Slotta-HuspeninaMohamed H. Abdel-RahmanDina AzizSue BellColleen M. CebullaAmy DavisRebecca DuellJ. Bradley ElderJoe HiltyBahavna KumarJames LangNorman L. LehmanRandy MandtPhuong NguyenRobert PilarskiKaran RaiLynn SchoenfieldKelly SenecalPaul WakelyPaul HansenRonald LechanJames PowersArthur TischlerWilliam E. GrizzleKatherine C. SextonAlison KastlJoel HendersonSima PortenJens WaldmannMartin FassnachtSylvia L. AsaDirk SchadendorfMarta CouceMarkus GraefenHartwig HulandGuido SauterThorsten SchlommRonald SimonPierre TennstedtOluwole OlabodeMark NelsonOliver BathePeter R. CarrollJune M. ChanPhilip DisaiaPat GlennRobin K. KelleyCharles N. LandenJoanna PhillipsMichael PradosJeffry SimkoKaren Smith-McCuneScott VandenBergKevin RogginAshley FehrenbachAdy KendlerSuzanne SifriRuth SteeleAntonio JimenoFrancis CareyIan ForgieMassimo MannelliMichael CarneyBrenda HernandezBenito CamposChristel Herold-MendeChristin JungkAndreas UnterbergAndreas von DeimlingAaron BosslerJoseph GalbraithLaura JacobusMichael KnudsonTina KnutsonDeqin MaMohammed MilhemRita SigmundAndrew K. GodwinRashna MadanHoward G. RosenthalClement AdebamowoSally N. AdebamowoAlex BoussioutasDavid BeerThomas GiordanoAnne-Marie Mes-MassonFred SaadTherese BocklageLisa LandrumRobert MannelKathleen MooreKatherine MoxleyRussel PostierJoan WalkerRosemary ZunaMichael FeldmanFederico ValdiviesoRajiv DhirJames LuketichEdna M. Mora PineroMario Quintero-AguiloCarlos Gilberto Carlotti, Jr.Jose Sebastião Dos SantosRafael KempAjith SankarankutyDaniela TirapelliJames CattoKathy AgnewElizabeth SwisherJenette CreaneyBruce RobinsonCarl Simon ShelleyEryn M. GodwinSara KendallCassaundra ShipmanCarol BradfordThomas CareyAndrea HaddadJeffey MoyerLisa PetersonMark PrinceLaura RozekGregory WolfRayleen BowmanKwun M. FongIan YangRobert KorstW. Kimryn RathmellJ. Leigh Fantacone-CampbellJeffrey A. HookeAlbert J. KovatichCraig D. ShriverJohn DiPersioBettina DrakeRamaswamy GovindanSharon HeathTimothy LeyBrian Van TinePeter WesterveltMark A. RubinJung Il LeeNatália D. AredesArmaz MariamidzeTexas Children’s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USATexas Children’s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USATexas Children’s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USABioinformatics Center, Molecular Medicine Research Center, Chang Gung University, Taoyuan, TaiwanDepartment of Surgery, Baylor College of Medicine, Houston, TX 77030, USATexas Children’s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USADepartment of Biology and Biochemistry, University of Houston, Houston, TX 77030, USADepartment of Biology and Biochemistry, University of Houston, Houston, TX 77030, USADepartment of Biology and Biochemistry, University of Houston, Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, Division of Surgery, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Biology and Biochemistry, University of Houston, Houston, TX 77030, USATexas Children’s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Corresponding authorSummary: Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs) whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts. To demonstrate proof of concept, we showed that perturbations targeting OIP5-AS1 (an inferred tumor suppressor) and TUG1 and WT1-AS (inferred onco-lncRNAs) dysregulated cancer genes and altered proliferation of breast and gynecologic cancer cells. Our analysis indicates that, although most lncRNAs are dysregulated in a tumor-specific manner, some, including OIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergistically dysregulate cancer pathways in multiple tumor contexts. : Chiu et al. present a pan-cancer analysis of lncRNA regulatory interactions. They suggest that the dysregulation of hundreds of lncRNAs target and alter the expression of cancer genes and pathways in each tumor context. This implies that hundreds of lncRNAs can alter tumor phenotypes in each tumor context. Keywords: lncRNA, regulation, modulation, cancer gene, pan-cancer, noncoding RNA, microRNA, RNA-binding proteins, interactomehttp://www.sciencedirect.com/science/article/pii/S221112471830425X |