Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia

Estrogen receptor α phosphorylated at Ser216 confers inflammatory function to mouse microglia

Abstract Background Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within the DNA binding domain. Previously, Ser216 was found to be phosphorylated...

Full description

Bibliographic Details
Main Authors: Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong, Masahiko Negishi
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Cell Communication and Signaling
Subjects:
Nuclear receptor
Estrogen receptor
Brain
Microglia
Inflammation
Phosphorylation
Online Access:http://link.springer.com/article/10.1186/s12964-020-00578-x

Internet

http://link.springer.com/article/10.1186/s12964-020-00578-x

Similar Items