Genetic analysis of Wnt/PCP genes in neural tube defects

Genetic analysis of Wnt/PCP genes in neural tube defects

Abstract Background Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) through the disruption of normal morphogenetic processes critical to neural tube closure (NTC). Knockout mice that are heterozygotes of single PCP genes li...

Full description

Bibliographic Details
Main Authors: Zhongzhong Chen, Yunping Lei, Xuanye Cao, Yufang Zheng, Fang Wang, Yihua Bao, Rui Peng, Richard H. Finnell, Ting Zhang, Hongyan Wang
Format: Article
Language:English
Published: BMC 2018-04-01
Series:BMC Medical Genomics
Subjects:
Neural tube defects
PCP (planar cell polarity)
Wnt
Variant
CELSR
Online Access:http://link.springer.com/article/10.1186/s12920-018-0355-9

Internet

http://link.springer.com/article/10.1186/s12920-018-0355-9

Similar Items