Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling

Poly-N-Acetyllactosamine Neo-Glycoproteins as Nanomolar Ligands of Human Galectin-3: Binding Kinetics and Modeling

Galectin-3 (Gal-3) is recognized as a prognostic marker in several cancer types. Its involvement in tumor development and proliferation makes this lectin a promising target for early cancer diagnosis and anti-cancer therapies. Gal-3 recognizes poly-N-acetyllactosamine (LacNAc)-based carbohydrate mot...

Full description

Bibliographic Details
Main Authors: Ladislav Bumba, Dominic Laaf, Vojtěch Spiwok, Lothar Elling, Vladimír Křen, Pavla Bojarová
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
carbohydrate
galectin-3
galectins in diagnosis
galectins in therapy
glycosyltransferase
surface plasmon resonance
molecular modeling
Online Access:http://www.mdpi.com/1422-0067/19/2/372

Internet

http://www.mdpi.com/1422-0067/19/2/372

Similar Items