Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet
This study evaluated the antioxidant activity and anti-diabetic effect of mulberry (Morus alba L. wielkolistna zolwinska) leaf extracts in diabetic rats fed a high-fat diet. After initial 4-week high-fat diet, streptozotocin was injected in Wistar rats to induce non-obese type 2 diabetes. After conf...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-05-01
|
Series: | Journal of Functional Foods |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614000681 |
id |
doaj-f486d222480645bab617b9e41b8eefda |
---|---|
record_format |
Article |
spelling |
doaj-f486d222480645bab617b9e41b8eefda2021-04-29T04:42:19ZengElsevierJournal of Functional Foods1756-46462014-05-018917Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat dietMagdalena Jeszka-Skowron0Ewa Flaczyk1Jan Jeszka2Zbigniew Krejpcio3Ewelina Król4Maciej S. Buchowski5Department of Chemistry and Technical Electrochemistry, Poznan University of Technology, Piotrowo 3, 60-965 Poznań, Poland; Corresponding author. Tel.: +4861-665-2314; fax: +4861-665-2571.Department of Food Service and Catering, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, PolandDepartment of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, PolandDepartment of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, PolandDepartment of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 31, 60-624 Poznan, PolandDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, Nashville, TN 37072, USAThis study evaluated the antioxidant activity and anti-diabetic effect of mulberry (Morus alba L. wielkolistna zolwinska) leaf extracts in diabetic rats fed a high-fat diet. After initial 4-week high-fat diet, streptozotocin was injected in Wistar rats to induce non-obese type 2 diabetes. After confirmation of diabetes, animals were treated with mulberry dried leaves, leaf-derived ethanol or acetone extracts added to high-fat diet for 4 weeks. Mulberry ethanol extract with higher level of phenolics – chlorogenic acid and flavonol glucosides was more effective than acetone extract or dry leaves in the lowering of blood glucose, increasing insulin level and markers of antioxidant activity. The results confirm key mechanisms related to the effect of mulberry and its bioactive components on modulation of glucose metabolism through correcting hyperglycaemia, increasing insulin secretion, and improving antioxidant status in STZ-induced non-obese diabetic rat model. Antidiabetic effects exerted by mulberry leaves might depend on the extraction process.http://www.sciencedirect.com/science/article/pii/S1756464614000681MulberryDiabetic ratsCarbohydrate metabolismAntioxidant activityPhenolicsHigh-fat diet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Magdalena Jeszka-Skowron Ewa Flaczyk Jan Jeszka Zbigniew Krejpcio Ewelina Król Maciej S. Buchowski |
spellingShingle |
Magdalena Jeszka-Skowron Ewa Flaczyk Jan Jeszka Zbigniew Krejpcio Ewelina Król Maciej S. Buchowski Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet Journal of Functional Foods Mulberry Diabetic rats Carbohydrate metabolism Antioxidant activity Phenolics High-fat diet |
author_facet |
Magdalena Jeszka-Skowron Ewa Flaczyk Jan Jeszka Zbigniew Krejpcio Ewelina Król Maciej S. Buchowski |
author_sort |
Magdalena Jeszka-Skowron |
title |
Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet |
title_short |
Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet |
title_full |
Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet |
title_fullStr |
Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet |
title_full_unstemmed |
Mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (STZ)-induced diabetic rats fed high-fat diet |
title_sort |
mulberry leaf extract intake reduces hyperglycaemia in streptozotocin (stz)-induced diabetic rats fed high-fat diet |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2014-05-01 |
description |
This study evaluated the antioxidant activity and anti-diabetic effect of mulberry (Morus alba L. wielkolistna zolwinska) leaf extracts in diabetic rats fed a high-fat diet. After initial 4-week high-fat diet, streptozotocin was injected in Wistar rats to induce non-obese type 2 diabetes. After confirmation of diabetes, animals were treated with mulberry dried leaves, leaf-derived ethanol or acetone extracts added to high-fat diet for 4 weeks. Mulberry ethanol extract with higher level of phenolics – chlorogenic acid and flavonol glucosides was more effective than acetone extract or dry leaves in the lowering of blood glucose, increasing insulin level and markers of antioxidant activity. The results confirm key mechanisms related to the effect of mulberry and its bioactive components on modulation of glucose metabolism through correcting hyperglycaemia, increasing insulin secretion, and improving antioxidant status in STZ-induced non-obese diabetic rat model. Antidiabetic effects exerted by mulberry leaves might depend on the extraction process. |
topic |
Mulberry Diabetic rats Carbohydrate metabolism Antioxidant activity Phenolics High-fat diet |
url |
http://www.sciencedirect.com/science/article/pii/S1756464614000681 |
work_keys_str_mv |
AT magdalenajeszkaskowron mulberryleafextractintakereduceshyperglycaemiainstreptozotocinstzinduceddiabeticratsfedhighfatdiet AT ewaflaczyk mulberryleafextractintakereduceshyperglycaemiainstreptozotocinstzinduceddiabeticratsfedhighfatdiet AT janjeszka mulberryleafextractintakereduceshyperglycaemiainstreptozotocinstzinduceddiabeticratsfedhighfatdiet AT zbigniewkrejpcio mulberryleafextractintakereduceshyperglycaemiainstreptozotocinstzinduceddiabeticratsfedhighfatdiet AT ewelinakrol mulberryleafextractintakereduceshyperglycaemiainstreptozotocinstzinduceddiabeticratsfedhighfatdiet AT maciejsbuchowski mulberryleafextractintakereduceshyperglycaemiainstreptozotocinstzinduceddiabeticratsfedhighfatdiet |
_version_ |
1721502000919609344 |