Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

Summary: Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2 main protease (Mpro) and...

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Bibliographic Details
Main Authors: Khushboo Bafna, Kris White, Balasubramanian Harish, Romel Rosales, Theresa A. Ramelot, Thomas B. Acton, Elena Moreno, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo García-Sastre, Robert M. Krug, Gaetano T. Montelione
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
COVID-19
SARS-CoV-2 3CL/Mpro protease
SARS-CoV-2 PL protease
HCV protease inhibitors
molecular docking
SARS-CoV-2 virus replication
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004721

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http://www.sciencedirect.com/science/article/pii/S2211124721004721

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