In Silico Prediction, Molecular Docking and Dynamics Studies of Steroidal Alkaloids of <i>Holarrhena pubescens</i> Wall. ex G. Don to Guanylyl Cyclase C: Implications in Designing of Novel Antidiarrheal Therapeutic Strategies

In Silico Prediction, Molecular Docking and Dynamics Studies of Steroidal Alkaloids of <i>Holarrhena pubescens</i> Wall. ex G. Don to Guanylyl Cyclase C: Implications in Designing of Novel Antidiarrheal Therapeutic Strategies

The binding of heat stable enterotoxin (STa) secreted by enterotoxigenic <i>Escherichia coli</i> (ETEC) to the extracellular domain of guanylyl cyclase c (ECD<sub>GC-C</sub>) causes activation of a signaling cascade, which ultimately results in watery diarrhea. We carried out...

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Bibliographic Details
Main Authors: Neha Gupta, Saurav Kumar Choudhary, Neeta Bhagat, Muthusamy Karthikeyan, Archana Chaturvedi
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
diarrhea
enterotoxigenic <i>E. coli</i> (ETEC)
extracellular domain (ECD) of GC-C
guanylyl cyclase c (GC-C)
heat stable enterotoxin (STa)
steroidal alkaloids
Online Access:https://www.mdpi.com/1420-3049/26/14/4147

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https://www.mdpi.com/1420-3049/26/14/4147

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