Oncogenic K-Ras Signals through Epidermal Growth Factor Receptor and Wild-Type H-Ras to Promote Radiation Survival in Pancreatic and Colorectal Carcinoma Cells

Oncogenic K-Ras Signals through Epidermal Growth Factor Receptor and Wild-Type H-Ras to Promote Radiation Survival in Pancreatic and Colorectal Carcinoma Cells

Pancreatic and colorectal carcinomas frequently express oncogenic/mutant K-Ras that contributes to both tumorigenesis and clinically observed resistance to radiation treatment. We have previously shown that farnesyltransferase inhibitors (FTI) radiosensitize many pancreatic and colorectal cancer ce...

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Bibliographic Details
Main Authors: Keith A. Cengel, K. Rahn Voong, Sanjay Chandrasekaran, Laurence Maggiorella, Thomas B. Brunner, Eric Stanbridge, Gary D. Kao, W. Gillies McKenna, Eric J. Bernhard
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Ras
EGFR
radiosensitivity
signal transduction
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607801047

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http://www.sciencedirect.com/science/article/pii/S1476558607801047

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