Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines

Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines

Outcome in high-risk patients with refractory or relapsed germ cell tumours (GCT) remains poor. Novel strategies enhancing therapeutic efficacy whilst limiting therapeutic burden are warranted, yet immunotherapy approaches geared towards activating endogenous antitumor responses have not been succes...

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Bibliographic Details
Main Authors: Stefan Schönberger, Daniela Kraft, Daniel Nettersheim, Hubert Schorle, Anna Casati, Rogerio B. Craveiro, Mahsa Mir Mohseni, Gabriele Calaminus, Dagmar Dilloo
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
EpCAM
CD3
bispecific antibody
immunotherapy
Catumaxomab
germ cell tumors
Online Access:https://www.mdpi.com/2072-6694/12/5/1279

Internet

https://www.mdpi.com/2072-6694/12/5/1279

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