Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase
<p>Abstract</p> <p>Background</p> <p>N348I in HIV-1 reverse transcriptase (RT) confers resistance to zidovudine (AZT) and nevirapine. Biochemical studies demonstrated that N348I indirectly increases AZT resistance by decreasing the frequency of secondary ribonuclease H...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-08-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/8/1/69 |