Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia

Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia

Abstract Background There is an urgent need for novel and effective treatment options for acute myeloid leukemia (AML). Triptolide, a diterpenoid tri-epoxide compound isolated from the herb Tripterygium wilfordii and its water-soluble pro-drug-Minnelide have shown promising anti-cancer activity. A r...

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Bibliographic Details
Main Authors: Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts, Ashok Saluja
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Translational Medicine
Subjects:
Minnelide
Acute myeloid leukemia
c-Myc
AML
Triptolide
Online Access:http://link.springer.com/article/10.1186/s12967-019-1901-8

Internet

http://link.springer.com/article/10.1186/s12967-019-1901-8

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