Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy

Abstract Disseminated cancer cells (DCCs) are detected in the circulation and bone marrow of up to 40% of breast cancer (BC) patients with clinically localized disease. The formation of metastases is governed by eco-evolutionary interactions of DCCs with the tissue during the transition from microsc...

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Bibliographic Details
Main Authors: Yael Artzy-Randrup, Tamir Epstein, Joel S. Brown, Ricardo L. B. Costa, Brian J. Czerniecki, Robert A. Gatenby
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-021-00230-y