A Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFN-β Production by Inducing Ubiquitination of RIG-I

A Comparative Analysis of Coronavirus Nucleocapsid (N) Proteins Reveals the SADS-CoV N Protein Antagonizes IFN-β Production by Inducing Ubiquitination of RIG-I

Coronaviruses (CoVs) are a known global threat, and most recently the ongoing COVID-19 pandemic has claimed more than 2 million human lives. Delays and interference with IFN responses are closely associated with the severity of disease caused by CoV infection. As the most abundant viral protein in i...

Full description

Bibliographic Details
Main Authors: Yan Liu, Qi-Zhang Liang, Wan Lu, Yong-Le Yang, Ruiai Chen, Yao-Wei Huang, Bin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
coronavirus
swine acute diarrhea syndrome coronavirus (SADS-CoV)
nucleocapsid protein
interferon
retinoic acid-inducible gene I (RIG-I)
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.688758/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.688758/full

Similar Items