GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin PathwaySummary

GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin PathwaySummary

Background & Aims: Transforming growth factor (TGF-β)–induced activation of quiescent hepatic stellate cells (HSCs) and their transformation to myofibroblasts is a key event in liver fibrosis and portal hypertension. GIPC (also referred to as synectin) is a downstream signal activation molec...

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Bibliographic Details
Main Authors: Usman Yaqoob, Fanghong Luo, Thomas Greuter, Nidhi Jalan Sakrikar, Tejasav S. Sehrawat, Jianwen Lu, Xiao Hu, Jinhang Gao, Enis Kostallari, Jingbiao Chen, Juan Pablo Arab, Rosa Martin-Mateos, Sheng Cao, Vijay H. Shah
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Fibrosis
Hepatic Stellate Cells
IGFBP-3
Integrin Signaling
Liver
Migration
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X20300758

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http://www.sciencedirect.com/science/article/pii/S2352345X20300758

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