Dendritic cells crosspresent antigens from live B16 cells more efficiently than from apoptotic cells and protect from melanoma in a therapeutic model.

Dendritic cells crosspresent antigens from live B16 cells more efficiently than from apoptotic cells and protect from melanoma in a therapeutic model.

Dendritic cells (DC) are able to elicit anti-tumoral CD8(+) T cell responses by cross-presenting exogenous antigens in association with major histocompatibility complex (MHC) class I molecules. Therefore they are crucial actors in cell-based cancer immunotherapy. Although apoptotic cells are usually...

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Bibliographic Details
Main Authors: Diana Matheoud, Camille Baey, Lene Vimeux, Andy Tempez, Michael Valente, Pauline Louche, Agnès Le Bon, Anne Hosmalin, Vincent Feuillet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084260?pdf=render

Internet

http://europepmc.org/articles/PMC3084260?pdf=render

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