Adipocyte OGT governs diet-induced hyperphagia and obesity

Adipocyte OGT governs diet-induced hyperphagia and obesity

Endocannabinoid signaling regulates food intake and is a potential therapeutic target for obesity. Here the authors show that adipocyte O-GlcNAc transferase (OGT) is required for high fat diet-induced hyperphagia via transcriptional activation of de novo lipid desaturation and accumulation of an end...

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Bibliographic Details
Main Authors: Min-Dian Li, Nicholas B. Vera, Yunfan Yang, Bichen Zhang, Weiming Ni, Enida Ziso-Qejvanaj, Sheng Ding, Kaisi Zhang, Ruonan Yin, Simeng Wang, Xu Zhou, Ethan X. Fang, Tian Xu, Derek M. Erion, Xiaoyong Yang
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07461-x

Internet

https://doi.org/10.1038/s41467-018-07461-x

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