Pharmacokinetic Evaluation of Metabolic Drug Interactions between Repaglinide and Celecoxib by a Bioanalytical HPLC Method for Their Simultaneous Determination with Fluorescence Detection

Pharmacokinetic Evaluation of Metabolic Drug Interactions between Repaglinide and Celecoxib by a Bioanalytical HPLC Method for Their Simultaneous Determination with Fluorescence Detection

Since diabetes mellitus and osteoarthritis are highly prevalent diseases, combinations of antidiabetic agents like repaglinide (REP) and non-steroidal anti-inflammatory drugs (NSAID) like celecoxib (CEL) could be commonly used in clinical practice. In this study, a simple and sensitive bioanalytical...

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Bibliographic Details
Main Authors: Dong-Gyun Han, Jinsook Kwak, Seong-Wook Seo, Ji-Min Kim, Jin-Wook Yoo, Yunjin Jung, Yun-Hee Lee, Min-Soo Kim, Young-Suk Jung, Hwayoung Yun, In-Soo Yoon
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pharmaceutics
Subjects:
celecoxib
drug–drug interaction
fluorescence
HPLC
metabolism
repaglinide
Online Access:https://www.mdpi.com/1999-4923/11/8/382

Internet

https://www.mdpi.com/1999-4923/11/8/382

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