Inferring spatial and signaling relationships between cells from single cell transcriptomic data

Dissociation of tissues allows high-throughput expression profiling of single cells, but spatial information is lost. Here the authors apply an unbalanced and structured optimal transport method to infer spatial and signalling relationships between cells from scRNA-seq data by integrating it with sp...

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Bibliographic Details
Main Authors: Zixuan Cang, Qing Nie
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15968-5