Loss of Janus Associated Kinase 1 Alters Urothelial Cell Function and Facilitates the Development of Bladder Cancer

Loss of Janus Associated Kinase 1 Alters Urothelial Cell Function and Facilitates the Development of Bladder Cancer

Inherited Primary Immunodeficiency (PID) disorders are associated with increased risk of malignancy that may relate to impaired antitumor immune responses or a direct role for PID germline mutations in tumorigenesis. We recently identified germline loss of function mutations in Janus Associated Kina...

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Bibliographic Details
Main Authors: Vanessa Daza-Cajigal, Adriana S. Albuquerque, Joanna Pearson, Jennifer Hinley, Andrew S. Mason, Jens Stahlschmidt, Adrian J. Thrasher, Vibhash Mishra, Jennifer Southgate, Siobhan O. Burns
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
bladder cancer
IFNγ signaling
immunodeficiency
JAK1
urothelium
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02065/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02065/full

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