Advanced glycation end products (AGEs) increase renal lipid accumulation: a pathogenic factor of diabetic nephropathy (DN)

Advanced glycation end products (AGEs) increase renal lipid accumulation: a pathogenic factor of diabetic nephropathy (DN)

Abstract Background Advanced glycation end products (AGEs) are pathogenic factors of diabetic nephropathy (DN), causing renal damage in various ways. The aim of this study is to investigate the ectopic lipid accumulation caused by AGEs in human renal tubular epithelial cell line (HK-2) cells and the...

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Bibliographic Details
Main Authors: Yang Yuan, Hong Sun, Zilin Sun
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Lipids in Health and Disease
Subjects:
Nε-(carboxymethyl) lysine (CML)
3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR)
LDL receptor (LDLr)
Sterol regulatory element binding protein-2 (SREBP-2)
SREBP cleavage-activating protein (SCAP)
Diabetic nephropathy (DN)
Online Access:http://link.springer.com/article/10.1186/s12944-017-0522-6

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http://link.springer.com/article/10.1186/s12944-017-0522-6

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