ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization <it>in vivo</it>
<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1α and STAT3 have been implica...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2008-07-01
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Series: | BMC Cancer |
Online Access: | http://www.biomedcentral.com/1471-2407/8/206 |