ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization <it>in vivo</it>

ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization <it>in vivo</it>

<p>Abstract</p> <p>Background</p> <p>Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro-angiogenic transcription factors HIF-1α and STAT3 have been implica...

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Bibliographic Details
Main Authors: Schlitt Hans J, Hellerbrand Claus, Mori Akira, Lang Sven A, Moser Christian, Geissler Edward K, Fogler William E, Stoeltzing Oliver
Format: Article
Language:English
Published: BMC 2008-07-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/206

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http://www.biomedcentral.com/1471-2407/8/206

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