Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway

Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway

Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer’s disease (AD) pathogenesis. Thus, inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The development of agent candidates by cultured n...

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Bibliographic Details
Main Authors: Nana Chen, Jiao Wang, Yuqi He, Yingshu Xu, Yuchuan Zhang, Qihai Gong, Changyin Yu, Jianmei Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
Aβ25–35
HT22 cells
Trilobatin
p38
Sirt3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00584/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00584/full

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