Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

Kinesins are a superfamily of microtubule-based ATP-powered motors, important for multiple, essential cellular functions. How microtubule binding stimulates their ATPase and controls force generation is not understood. To address this fundamental question, we visualized microtubule-bound kinesin-1 a...

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Bibliographic Details
Main Authors: Joseph Atherton, Irene Farabella, I-Mei Yu, Steven S Rosenfeld, Anne Houdusse, Maya Topf, Carolyn A Moores
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-09-01
Series:eLife
Subjects:
microtubule
kinesin
cryo-electron microscopy
motor
cytoskeleton
ATPase
Online Access:https://elifesciences.org/articles/03680

Internet

https://elifesciences.org/articles/03680

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