Single Molecule Analysis of Laser Localized Interstrand Crosslinks

Single Molecule Analysis of Laser Localized Interstrand Crosslinks

DNA interstrand crosslinks (ICLs) block unwinding of the double helix, and have always been regarded as major challenges to replication and transcription. Compounds that form these lesions are very toxic and are frequently used in cancer chemotherapy. We have developed two strategies, both based on...

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Bibliographic Details
Main Authors: Jing eHuang, Himabindu eGali, Manikandan eParamasivam, Parameswary eMuniandy, Julia eGichimu, Marina Andrea Bellani, Michael M Seidman
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Genetics
Subjects:
DNA Damage
replication
laser
Single molecule
Interstrand crosslinks
DNA fiber
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00084/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00084/full

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