Effects of combined therapy of alendronate and low-intensity pulsed ultrasound on metaphyseal bone repair after osteotomy in the proximal tibia of glucocorticoid-induced osteopenia rats

Effects of combined therapy of alendronate and low-intensity pulsed ultrasound on metaphyseal bone repair after osteotomy in the proximal tibia of glucocorticoid-induced osteopenia rats

Objectives: Glucocorticoid (GC) treatment inhibits activation of runt-related transcription factor 2 (Runx2), which is essential for osteoblast differentiation from stem cells. As a result, GC treatment results in bone loss, GC-induced osteoporosis (GIO), elevated fracture risk, and delayed bone hea...

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Bibliographic Details
Main Authors: Tetsuya Kawano, Naohisa Miyakoshi, Yuji Kasukawa, Michio Hongo, Hiroyuki Tsuchie, Chie Sato, Masashi Fujii, Masazumi Suzuki, Manabu Akagawa, Yuichi Ono, Yusuke Yuasa, Itsuki Nagahata, Yoichi Shimada
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Osteoporosis and Sarcopenia
Subjects:
Glucocorticoid
Osteoporosis
Bisphosphonate
Online Access:http://www.sciencedirect.com/science/article/pii/S2405525517300730

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http://www.sciencedirect.com/science/article/pii/S2405525517300730

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