GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.

Bibliographic Details
Main Authors: Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18247-5

Internet

https://doi.org/10.1038/s41467-020-18247-5

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