GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.

Bibliographic Details
Main Authors:	Bradley M. Roberts, Natalie M. Doig, Katherine R. Brimblecombe, Emanuel F. Lopes, Ruth E. Siddorn, Sarah Threlfell, Natalie Connor-Robson, Nora Bengoa-Vergniory, Nicholas Pasternack, Richard Wade-Martins, Peter J. Magill, Stephanie J. Cragg
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18247-5

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spelling	doaj-f4c24c167c97494e92ebdf24a52294962021-10-03T11:52:19ZengNature Publishing GroupNature Communications2041-17232020-10-0111111710.1038/s41467-020-18247-5GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism modelBradley M. Roberts0Natalie M. Doig1Katherine R. Brimblecombe2Emanuel F. Lopes3Ruth E. Siddorn4Sarah Threlfell5Natalie Connor-Robson6Nora Bengoa-Vergniory7Nicholas Pasternack8Richard Wade-Martins9Peter J. Magill10Stephanie J. Cragg11Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordOxford Parkinson’s Disease Centre, University of OxfordCentre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of OxfordGABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.https://doi.org/10.1038/s41467-020-18247-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bradley M. Roberts Natalie M. Doig Katherine R. Brimblecombe Emanuel F. Lopes Ruth E. Siddorn Sarah Threlfell Natalie Connor-Robson Nora Bengoa-Vergniory Nicholas Pasternack Richard Wade-Martins Peter J. Magill Stephanie J. Cragg
spellingShingle	Bradley M. Roberts Natalie M. Doig Katherine R. Brimblecombe Emanuel F. Lopes Ruth E. Siddorn Sarah Threlfell Natalie Connor-Robson Nora Bengoa-Vergniory Nicholas Pasternack Richard Wade-Martins Peter J. Magill Stephanie J. Cragg GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model Nature Communications
author_facet	Bradley M. Roberts Natalie M. Doig Katherine R. Brimblecombe Emanuel F. Lopes Ruth E. Siddorn Sarah Threlfell Natalie Connor-Robson Nora Bengoa-Vergniory Nicholas Pasternack Richard Wade-Martins Peter J. Magill Stephanie J. Cragg
author_sort	Bradley M. Roberts
title	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_short	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_full	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_fullStr	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_full_unstemmed	GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
title_sort	gaba uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.
url	https://doi.org/10.1038/s41467-020-18247-5
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GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

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