Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study

Endothelial Reprogramming by Disturbed Flow Revealed by Single-Cell RNA and Chromatin Accessibility Study

Summary: Disturbed flow (d-flow) induces atherosclerosis by regulating gene expression in endothelial cells (ECs). For further mechanistic understanding, we carried out a single-cell RNA sequencing (scRNA-seq) and scATAC-seq study using endothelial-enriched single cells from the left- and right caro...

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Bibliographic Details
Main Authors: Aitor Andueza, Sandeep Kumar, Juyoung Kim, Dong-Won Kang, Hope L. Mumme, Julian I. Perez, Nicolas Villa-Roel, Hanjoong Jo
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
single-cell RNA sequencing
single-cell ATAC sequencing
endothelium
blood flow
endothelial-to-mesenchymal transition
reprogramming
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314807

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http://www.sciencedirect.com/science/article/pii/S2211124720314807

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