Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions

Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions

Since Huggins defined the androgen-sensitive nature of prostate cancer (PCa), suppression of systemic testosterone (T) has remained the most effective initial therapy for advanced disease although progression inevitably occurs. From the inception of clinical efforts to suppress androgen receptor (AR...

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Bibliographic Details
Main Authors: Osama S. Mohammad, Michael D. Nyquist, Michael T. Schweizer, Stephen P. Balk, Eva Corey, Stephen Plymate, Peter S. Nelson, Elahe A. Mostaghel
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Cancers
Subjects:
high dose testosterone
supraphysiologic androgen
bipolar androgen therapy
biphasic
BAT
castration resistant prostate cancer
CRPC
Online Access:https://www.mdpi.com/2072-6694/9/12/166

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https://www.mdpi.com/2072-6694/9/12/166

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