A Novel Screen for Expression Regulators of the Telomeric Protein TRF2 Identified Small Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth

A Novel Screen for Expression Regulators of the Telomeric Protein TRF2 Identified Small Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth

Telomeric repeat-binding factor 2 (TRF2) is a subunit of the shelterin protein complex, which binds to and protects telomeres from unwanted DNA damage response (DDR) activation. TRF2 expression plays a pivotal role in aging and cancer, being downregulated during cellular senescence and overexpressed...

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Bibliographic Details
Main Authors: Mounir El Maï, Serena Janho dit Hreich, Cedric Gaggioli, Armelle Roisin, Nicole Wagner, Jing Ye, Pierre Jalinot, Julien Cherfils-Vicini, Eric Gilson
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
TRF2
cancer
aging
cell-based screening assay
neo-angiogenesis
immune suppression
Online Access:https://www.mdpi.com/2072-6694/13/12/2998

Internet

https://www.mdpi.com/2072-6694/13/12/2998

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