Profiling donepezil template into multipotent hybrids with antioxidant properties

Profiling donepezil template into multipotent hybrids with antioxidant properties

Alzheimer’s disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist memantine. However, their therapeutic effect is only...

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Bibliographic Details
Main Authors: Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Acetylcholinesterase
Alzheimer’s disease
donepezil
multi-target directed ligands
oxidative stress
Online Access:http://dx.doi.org/10.1080/14756366.2018.1443326

Internet

http://dx.doi.org/10.1080/14756366.2018.1443326

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