Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.

Chronic inflammation in the stomach induces metaplasia, the pre-cancerous lesion that precedes inflammation-driven neoplastic transformation. While Hedgehog signaling contributes to the initiation of some cancers, its role in gastric transformation remains poorly defined. We found that Helicobacter-...

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Bibliographic Details
Main Authors: Mohamad El-Zaatari, John Y Kao, Art Tessier, Longchuan Bai, Michael M Hayes, Clinton Fontaine, Kathryn A Eaton, Juanita L Merchant
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3592845?pdf=render

Internet

http://europepmc.org/articles/PMC3592845?pdf=render

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