In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus

In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus

Abstract Background To evaluate the in vivo and in vitro toxicity of a new formulation of liposome-encapsulated sirolimus (LES). Methods In vitro experiments were done using ARPE-19 and HRP cells. An MTT assay was used to determine cell metabolic activity and a TUNEL assay for detecting DNA fragment...

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Bibliographic Details
Main Authors: Murilo Batista Abud, Ricardo Noguera Louzada, David Leonardo Cruvinel Isaac, Leonardo Gomes Souza, Ricardo Gomes dos Reis, Eliana Martins Lima, Marcos Pereira de Ávila
Format: Article
Language:English
Published: BMC 2019-09-01
Series:International Journal of Retina and Vitreous
Subjects:
Sirolimus
LES
ARPE-19
Rapamycin
Uveitis
Online Access:http://link.springer.com/article/10.1186/s40942-019-0186-7

Internet

http://link.springer.com/article/10.1186/s40942-019-0186-7

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