In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus
Abstract Background To evaluate the in vivo and in vitro toxicity of a new formulation of liposome-encapsulated sirolimus (LES). Methods In vitro experiments were done using ARPE-19 and HRP cells. An MTT assay was used to determine cell metabolic activity and a TUNEL assay for detecting DNA fragment...
Main Authors: | Murilo Batista Abud, Ricardo Noguera Louzada, David Leonardo Cruvinel Isaac, Leonardo Gomes Souza, Ricardo Gomes dos Reis, Eliana Martins Lima, Marcos Pereira de Ávila |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-09-01
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Series: | International Journal of Retina and Vitreous |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40942-019-0186-7 |
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