The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice.

The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice.

BACKGROUND: Thyroid hormones (TH) regulate cholesterol metabolism but their use as lipid-lowering drugs is restricted due to negative cardiac effects. TH mimetic compounds modulating TH receptor β (THRβ) have been designed as potential drugs, reducing serum cholesterol levels while avoiding apparent...

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Bibliographic Details
Main Authors: Lisa-Mari Mörk, Stefan Rehnmark, Padideh Davoodpour, Giuseppe Danilo Norata, Lilian Larsson, Michael-Robin Witt, Johan Malm, Paolo Parini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3850901?pdf=render

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http://europepmc.org/articles/PMC3850901?pdf=render

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