An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities

Rats of the Wistar Albino Glaxo/Rij (WAG/Rij) strain show symptoms resembling human absence epilepsy. Thalamocortical neurons of WAG/Rij rats are characterized by an increased HCN1 expression, a negative shift in Ih activation curve, and an altered responsiveness of Ih to cAMP. We cloned HCN1 channe...

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Bibliographic Details
Main Authors: Konstantin eWemhöner, Tatyana eKanyshkova, Nicole eSilbernagel, Juncal eFernandez-Orth, Stefan eBittner, Aytug K Kiper, Susanne eRinné, Michael F Netter, Sven G Meuth, Thomas eBudde, Niels eDecher
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
absence epilepsy
HCN
Ih
WAG/Rij rat
thalamocortical relay neurons
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00063/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2015.00063/full

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