Strategy for Treating Motor Neuron Diseases Using a Fusion Protein of Botulinum Toxin Binding Domain and Streptavidin for Viral Vector Access: Work in Progress

Strategy for Treating Motor Neuron Diseases Using a Fusion Protein of Botulinum Toxin Binding Domain and Streptavidin for Viral Vector Access: Work in Progress

Although advances in understanding of the pathogenesis of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) have suggested attractive treatment strategies, delivery of agents to motor neurons embedded within the spinal cord is problematic. We have designed a strategy based on the...

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Bibliographic Details
Main Authors: Uma Balasubramanian, Yang Lu, Daniel B. Drachman, Robert N. Adams
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Toxins
Subjects:
botulinum toxin
binding domain
motor neuron diseases
ALS
SMA
motor neurons
therapeutic targeting
gene transfer
viral vectors
Online Access:http://www.mdpi.com/2072-6651/2/12/2872/

Internet

http://www.mdpi.com/2072-6651/2/12/2872/

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