Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype.

Expression of Leukemia-Associated Nup98 Fusion Proteins Generates an Aberrant Nuclear Envelope Phenotype.

Chromosomal translocations involving the nucleoporin NUP98 have been described in several hematopoietic malignancies, in particular acute myeloid leukemia (AML). In the resulting chimeric proteins, Nup98's N-terminal region is fused to the C-terminal region of about 30 different partners, inclu...

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Main Authors: Birthe Fahrenkrog, Valérie Martinelli, Nadine Nilles, Gernot Fruhmann, Guillaume Chatel, Sabine Juge, Ursula Sauder, Danika Di Giacomo, Cristina Mecucci, Jürg Schwaller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4816316?pdf=render

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http://europepmc.org/articles/PMC4816316?pdf=render

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