Another Facet to the Anticancer Response to Lamellarin D: Induction of Cellular Senescence through Inhibition of Topoisomerase I and Intracellular Ros Production

Another Facet to the Anticancer Response to Lamellarin D: Induction of Cellular Senescence through Inhibition of Topoisomerase I and Intracellular Ros Production

Lamellarin D (LamD) is a marine alkaloid with broad spectrum antitumor activities. Multiple intracellular targets of LamD, which affect cancer cell growth and induce apoptosis, have been identified. These include nuclear topoisomerase I, relevant kinases (such as cyclin-dependent kinase 2) and the m...

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Bibliographic Details
Main Authors: Caroline Ballot, Alain Martoriati, Manel Jendoubi, Sébastien Buche, Pierre Formstecher, Laurent Mortier, Jérome Kluza, Philippe Marchetti
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Marine Drugs
Subjects:
oxidative stress response
mitochondria
DNA damage
cellular senescence
Online Access:http://www.mdpi.com/1660-3397/12/2/779

Internet

http://www.mdpi.com/1660-3397/12/2/779

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