Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

A quarter of the global human population is estimated to be latently infected by Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). TB remains the global leading cause of death by a single pathogen and ranks among the top-10 causes of overall global mortality. Current immuno...

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Bibliographic Details
Main Authors: Mariateresa Coppola, Raquel Villar-Hernández, Krista E. van Meijgaarden, Irene Latorre, Beatriz Muriel Moreno, Esther Garcia-Garcia, Kees L. M. C. Franken, Cristina Prat, Zoran Stojanovic, Maria Luiza De Souza Galvão, Joan-Pau Millet, Josefina Sabriá, Adrián Sánchez-Montalva, Antoni Noguera-Julian, Annemieke Geluk, Jose Domínguez, Tom H. M. Ottenhoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
IVE-TB antigens
Mycobacterium tuberculosis (Mtb)
TB
LTBI
cytokines
cell responses
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00103/full

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