Transcriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations.

Transcriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations.

BACKGROUND: Molecular mechanisms explaining age-related changes in the bone marrow with reduced precursor B cell output are poorly understood. METHODS: We studied the transcriptome of five precursor B cell subsets in individual bone marrow samples from 4 healthy children and 4 adults employing GeneC...

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Bibliographic Details
Main Authors: Kristin Jensen, Berit Sletbakk Brusletto, Hans Christian Dalsbotten Aass, Ole K Olstad, Peter Kierulf, Kaare M Gautvik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3728296?pdf=render

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http://europepmc.org/articles/PMC3728296?pdf=render

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