Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax).

Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax).

We have developed a manufacturing strategy that can improve the safety and genetic stability of recombinant live-attenuated chimeric dengue vaccine (DENVax) viruses. These viruses, containing the pre-membrane (prM) and envelope (E) genes of dengue serotypes 1-4 in the replicative background of the a...

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Main Authors: Claire Y-H Huang, Richard M Kinney, Jill A Livengood, Bethany Bolling, John J Arguello, Betty E Luy, Shawn J Silengo, Karen L Boroughs, Janae L Stovall, Akundi P Kalanidhi, Aaron C Brault, Jorge E Osorio, Dan T Stinchcomb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3667780?pdf=render

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http://europepmc.org/articles/PMC3667780?pdf=render

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