Paclitaxel-Loaded Silk Fibroin Nanoparticles: Method Validation by UHPLC-MS/MS to Assess an Exogenous Approach to Load Cytotoxic Drugs

Paclitaxel-Loaded Silk Fibroin Nanoparticles: Method Validation by UHPLC-MS/MS to Assess an Exogenous Approach to Load Cytotoxic Drugs

The aim of this work was to load an anticancer drug, paclitaxel (PTX), on Silk Fibroin Nanoparticles (SFNs) by using an exogenous approach. SFNs were produced, freeze-dried and then loaded with PTX. An exogenous method allowed us to reduce both drug loss and environmental impact. In order to quantif...

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Bibliographic Details
Main Authors: Sara Perteghella, Cristina Sottani, Valentina Coccè, Sara Negri, Loredana Cavicchini, Giulio Alessandri, Danilo Cottica, Maria Luisa Torre, Elena Grignani, Augusto Pessina
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
silk fibroin
nanoparticles
paclitaxel
UHPLC-MS/MS
method validation
Online Access:https://www.mdpi.com/1999-4923/11/6/285

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https://www.mdpi.com/1999-4923/11/6/285

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