A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects

A decrease in nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of aging in multiple organisms, including humans. We report a human clinical trial designed to assess the efficacy of single-dose supplementation of nicotinamide, a form of vitamin B3, on increasing NAD+ levels. Nicotinamide...

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Bibliographic Details
Main Authors: Takashi K. Ito, Tomohito Sato, Akio Hakamata, Yuki Onoda, Shumpei Sato, Fumiyoshi Yamazaki, Makoto Horikawa, Yutaka Takahashi, Takuya Kitamoto, Masako Suzuki, Shinya Uchida, Keiichi Odagiri, Mitsutoshi Setou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2020-01-01
Series:Translational Medicine of Aging
Subjects:
Clinical trial
Nicotinamide
NAD+
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2468501120300043

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http://www.sciencedirect.com/science/article/pii/S2468501120300043

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